Full Reference List
1. Lang JC, Whitelaw B, Talbot S and Wilkie NM (1988) Transcriptional regulation of human c-myc gene. Br J Cancer, 58, 62-66.
2. Clark AJ, Bessos H, Bishop JO, Brown P, Harris S, Lathe R, McClenaghan M, Prowse C, Simons JP, Whitelaw CBA and Wilmut I (1989) Expression of human anti-hemophilic factor IX in the milk transgenic sheep. Bio/Tech 7, 487-492.
3. Clark AJ, Ali S, Archibald AL, Bessos H, Brown P, Harris S, McClenaghan M, Prowse C, Simons JP, Whitelaw CBA and Wilmut, I (1989) The molecular manipulation of milk composition. Genome 31, 950-955.
4. Whitelaw CBA and Clark AJ (1989) Animal bioreactors. AgBiotech News and Information 1, 701-705.
5. Wilmut I, Archibald AL, Harris S, McClenaghan M, Simons JP, Whitelaw CBA and Clark AJ (1990) Methods of gene transfer and their potential use to modify milk composition. Theriogenol 33, 113-123.
6. Whitelaw CBA, Archibald AL, McClenaghan M, Harris S, Simons JP Watson CJ, Wilmut I and Clark AJ (1990) Expression of ß-lactoglobulin and hybrid transgenes in the mammary gland. Proc Biotech USA, pp. 130-136.
7. Clark AJ, Archibald AL, McClenaghan M, Simons JP, Whitelaw CBA and Wilmut I (1990) The germline manipulation of livestock: progress during the past five years. Proc NZ Soc Animal Prod 50, 167-179.
8. Lang JC, Wilkie NM, Clark AM, Chudleigh A, Talbot S, Whitelaw B and Frame MC (1991) Regulatory domains within the P0 promoter of human c-myc. Oncogene 6, 2067-2075.
9. Whitelaw CBA, Archibald AL, Harris S, McClenaghan M, Simons JP, Springbett A, Wallace R and Clark AJ (1990) Frequency of germline mosaicism in G0 transgenic mice. Mouse Genome 88, 114.
10. Whitelaw CBA, Archibald AL, Harris S, McClenaghan Simons JP and Clark AJ (1991) Targeting expression to the mammary gland: intronic sequencs can enhance the efficiency of gene expression in transgenic mice. Transgenic Res 1, 3-13.
11. McClenaghan M, Archibald AL, Harris S, Simons JP, Whitelaw CBA, Wilmut I and Clark, AJ (1991) Production of human 1-antitrypsin in the milk of transgenic sheep and mice: targeting expression of cDNA sequences to the mammary gland. Anim Biotech 2, 161-176.
12. Wilmut I, Archibald AL, McClenaghan M, Simons JP, Whitelaw CBA and Clark AJ (1991) Production of pharmaceutical proteins in milk. Experimentia 47, 905-912.
13. Whitelaw CBA, Harris S, McClenaghan M, Simons JP and Clark AJ (1992) Position-independent expression of the ovine ß-lactoglobulin gene in transgenic mice. Biochem J 286, 31-39.
14. Whitelaw CBA (1992) Transgenic animals as bioreactors. AgBiotech News and Information 4, 371N-372N.
15. Whitelaw CBA, Springbett A, Webster J and Clark AJ (1993) The majority of G0 transgenic mice are derived from mosaic embryos. Transgenic Res 2, 29-32.
16. Springbett AJ, Burdon T, Yull FE and Whitelaw CBA (1993) Comment on mosaic nature of G0 transgenic mice. Mouse Genome 91, 113.
17. Clark AJ, Archibald AL, McClenaghan M, Simons JP, Wallace R and Whitelaw CBA (1993) Enhancing the efficiency of transgene expression. Phil Trans R Soc Lond B 339, 225-232.
18. Clark AJ, Bissinger P, Bullock D, Damak S, Wallace R, Whitelaw CBA and Yull FE (1994) Chromosomal position effects and modulation of transgene expression. Reprod Fert Dev 6, 589-598.
19. Wilmut I and Whitelaw CBA (1994) Strategies for production of pharmaceutical proteins in milk. Reprod Fert Dev 6, 625-630.
20. Farini E and Whitelaw CBA (1995) Ectopic expression of ß-lactoglobulin transgenes. Mol Gen Genet 246, 834-837.
21. Whitelaw CBA (1995) Regulation of ovine ß-lactoglobulin gene expression during the first stage of lactogenesis. Biochem Biophys Res Comm 209, 1089-1093.
22. Webster J, Wallace R, Clark AJ and Whitelaw CBA (1995) Tissue-specific,temporally-regulated expression mediated by the proximal promoter of the ovine ß-lactoglobulin promoter in transgenic mice. Cel. Mol Biol Res 41, 11-15.
23. Streuli CH, Edwards GE, Delcommenne M, Whitelaw CBA, Burdon TG and Watson CJ (1995) Stat5 as a target for regulation by the extracellular matrix. J Biol Chem 270, 21639-21644.
24. Whitelaw CBA (1995) Pharmaceuticals from transgenic sheep. Biol Sci Rev 7, 25-27.
25. Donofrio G, Bignetti E, Clark AJ and Whitelaw CBA (1996) Comparable processing of ß-lactoglobulin pre-mRNA in cell culture and transgenic mouse models. Mol Gen Genet 252-465-469.
26. Whitelaw CBA (1996) Hormonal influences on ß-lactoglobulin transgene expression inferred from chromatin structure. Biochem Biophys Res Comm 224, 121-125.
27. Whitelaw CBA (1996) Truncated -lactoglobulin transgenes are expressed in the kidney. Gene 178, 157-159.
28. Webster J, Donofrio G, Wallace R, Clark AJ and Whitelaw CBA (1997) Intronic sequences modulate the sensitivity of ß-lactoglobulin transgenes to position-effects. Gene 193, 239-243.
29. Grolli S, Accornero P, Ramoni R, Donofrio G and Whitelaw CBA (1997) Expression of c-myc is down-regulated as mouse mammary epithelial cells become confluent. Biochem Biophys Res Comm 239, 566-569.
30. Sola I, Castilla J, Pintado B, Sanchez-Morgado JM, Whitelaw CBA, Clark AJ and Enjuanes L (1998) Transgenic mice secreting coronavirus neutalising antibodies into the milk. J Virol 72, 3762-3772.
31. Langley B, Vilotte JL, Stinnakre MG, Whitelaw CBA and L’Huillier P (1998) Rescue of MMTV transgene by co-intergration reveals locus control properties of the ovine -lactoglobulin gene. Transgenic Res 7, 205-211.
32. Whitelaw CBA and Webster J (1998) Temporal profile of DNaseI hypersensitive sites associated with the ß-lactoglobulin gene and transgenes. Mol Gen Genet 257, 649-654.
33. Pena RN, Folch, JM, Sanchez A and Whitelaw CBA (1998) Chromatin of goat and sheep ß-lactogloulin gene differ. Biochem Biophys Res Comm 252, 649-653.
34. Whitelaw CBA (1998) Chromatin structure of ß-lactoglobulin transgenes. Proc 1st Int. Workshop on Mammary Gland Biotechnology, pp. 31-34.
35. Whitelaw CBA and Webster J (1998) Chromatin heterogeneity within multicopy transgene arrays. Transgenic Res 7, 401-402.
36. Whitelaw CBA (1999) Toward designer milk. Nat Biotech 17, 135-136.
37. Whitelaw CBA Farini E and Webster J (1999) The changing role of cell culture in the generation of transgenic livestock. Cytotech 31, 3-8.
38. Whitelaw CBA and Clark AJ (1999) Optimisation of transgene expresssion in the mammary gland. in Animal and Cell Technology: Basic and Applied Aspects, Ed. Y Kitagawa, T Matsuda and S Iijima. Kluwer Academic Publishers, Dordrecht, The Netherlands.
39. Whitelaw CBA, Grolli S, Accornero P, Donofrio G and Webster J (2000) Matrix attachment region regulates basal -lactoglobulin transgene expression. Gene 244, 73-80.
40. Donofrio G, Cavirani S, Whitelaw CBA, Flammini CS and Scatozza F (2000) Transfection of bovine cell culture with Bovine herpesvirus 4 DNA obtained by cell nuclear extraction. Microbiol 23, 129-135.
41. James RM, Neil C, Clark AJ, Webster J, Roos S and Whitelaw CBA (2000) Multiple copies of beta-lactoglobulin promoter do not function as LCR. Biochem Biophys Res Comm 272, 284-289.
42. Tonner E, Allan G, Shkreta L, Webster J, Whitelaw B and Flint D (2000) Insulin-like growth factor binding protein-5 (IGFBP-5) potentially regulates programmed cell death and plasminogen activation in the mammary gland. Adv Exp Med Biol 480, 45-53
43. Whitelaw CBA (2000) Nucleosome organisation of the -lactoglobulin gene: transcription complex formation. Adv Exp Med Biol 480, 147-153.
44. Tywman RM and Whitelaw, CBA (2000) Genetic engineering: Animal cell technology. Encyclopedia of Cell Technology, pub. Wiley, pp. 737-819.
45. Christou P and Whitelaw CBA (2000) Frontiers in Transgenic Research. Transgenic Res 9, 241-242.
46. Kolb AF, Pewe L, Webster J, Perlman S, Whitelaw CBA and Siddell S (2001) A virus neutralising antibody expressed in milk of transgenic mice provides full protection against virus-induced encephalitis. J Virol 75, 2803-2809.
47. Flint DJ, Tonner E, Knight CH, Whitelaw CBA, Webster J, Barber M and Allan G (2001) Control of mammary involution by insulin-like growth factor binding proteins: role of prolactin. Livestock Prod Sci 70, 115-120.
48. Whitelaw CBA, Webster J, Kastanis P, Farini E, Osman F, Kaempfer R, Hiripi L and Bosze S (2001) Potential to exploit RNA processing elements in transgenic mice. Cloning Stem Cells 3, 170.
49. Kolb AF, Webster J, Whitelaw CBA and Siddell SG (2001) A virus-neutralising monoclonal antibody expressed in the milk of transgenic mice. Adv Exp Med Biol 494, 411-414.
50. Whitelaw CBA (2001) Pharmaceutical proteins in milk from transgenic animals. Encyclopedia of Genetics, pub. Fitzroy Dearbarn, pp. 370-373.
51. Whitelaw B (2001) Transgenic Animal Welfare. Transgenic Res 10, 375.
52. Gerencser A, Barta E, Boa S, Kastanis P, Bosze Z and Whitelaw CBA (2002) Comparative analysis of the structural features of the 5’-flanking region of the mouse and rabbit -casein genes. Genet Select Evol 34, 1-12.
53. Opsahl ML, McClenaghan M, Springbett A, Reid S, Lathe R, Colman A and Whitelaw CBA (2002) Multiple effects of genetic background on variegated transgene expression in mice. Genetics 160, 1107-112.
54. Tonner E, Barber M, Allan GJ, Webster J, Whitelaw CBA and Flint DJ (2002) Insulin-like growth factor binding protein-5 (IGFBP-5) induces premature cell death in the mammary gland of transgenic mice. Development 129, 4547-4557.
55. Whitelaw CBA and Bruce DM (2002) Does genetic modification violate intrinsic value? Trends Biotech 20, 488-489.
56. Pena R and Whitelaw B (2002) Recombinant protein production in milk. Bio Sci Rev 15, 39-41.
57. Opsahl ML, Springbett A, McClenaghan M, Lathe R, Colman A and Whitelaw CBA (2003) Trans-silencing by a variegated transgene in mice. Transgenic Res12, 661-699.
58. Clark AJ and Whitelaw CBA (2003) A future for transgenic livestock. Nat Rev Genet 4, 825-833.
59. Vilotte JL, Whitelaw CBA, Ollivier-Bousquet M and Shennan D (2003) Advanced Dairy Chemistry 3rd Edition, ed. P. Fox and P. McSweeney, Kluwer Academic, pp. 699-738.
60. Whitelaw CBA, Hiripi L, Farini E, Opsahl, ML and Bosze Z (2004) On the use of post-transcriptional processing elements in transgenes. Transgenic Res13, 75-79.
61. Pena RM, Webster J, Kwan S, Korbel J and Whitelaw CBA (2004) Transgene methylation in mice reflects copy-number but not expression level. Mol Biotechnol 26, 215-220.
62. Whitelaw CBA, Radcliffe PA, Ritchie WA, Carlisle A, Ellard F, Pena R, Rowe J, Clark AJ, King TJ and Mitrophanous KA (2004) Efficient generation of transgenic pigs using equine infectious anaemia virus (EIAV) derived vector. FEBS Lett 571, 233-236.
63. Whitelaw CBA (2004) Transgenic livestock made easy. Trends Biotech 22, 157-159.
64. Pena RN and Whitelaw CBA (2005) Duplication of Stat5-binding sites within the -lactoglobulin promoter compromises transcription in vitro. Biochimmie 87, 523-528.
65. Ritchie WA, Taylor JE, Gardner JO, Wilmut I, Carlisle A, Neil C, King T and Whitelaw CBA (2005) Live lambs born from zona-pellucida denuded embryos. Cloning Stem Cells 7, 178-182.
66. Flint DJ, Boutinaud M, Tonner E, Wilde C, Hurley W, Accorsi PA, Kolb A, Whitelaw CBA, Beattie J and Allan GJ (2005) Insulin-like growth factor binding proteins initiate cell death and extracellular matrix remodelling in the mammary gland. Dom Anim Endocrinol 29, 274-282.
67. Whitelaw CBA and Sang HM (2005) Disease Resistant Genetic Modified Animals. Rev Sci Tech 24, 275-283.
68. Whitelaw CBA (2005) Development of germline manipulation technologies in livestock. Applications of gene-based technologies for improving animal production and health in developing countries, ed. HPS Makkar and GJ Viljoen, Springer, pp. 99-109.
69. Kolb AF and Whitelaw CBA (2006) A virus-neutralising antibody is not cytotoxic in vitro. Mol Immunol 43, 677-89.
70. Flint DJ, Boutinard M, Whitelaw CBA, Allan GJ and Kolb AF (2006) Prolactin inhibits cell death and expression of matrix metallo-proteinases in the involuting mouse mammary gland but fails to prevent cell loss in the mammary glands of mice expressing Insulin-like Growth Factor Binding Protein (IGFBP)-5 as a mammary transgene. J Mol Endocrinol 36, 435-448.
71. Gencheva M, Boa S, Fraser R, Simmen MW, Whitelaw CBA and Allan J (2006) In vitro and in vivo nucleosome positioning on the ovine beta-lactoglobulin gene are related. J Mol Biol 361, 216-230.
72. Ritchie WA, Neil C, King T and Whitelaw CBA (2007) Transgenic mice produced from low titre lentiviral vectors. Transgenic Res 16, 661-664.
73. Suk J, Bruce A, Gertz R, Warkup C, Whitelaw CBA, Braun A, Oram C and Papatryfon I (2007) Dolly for Dinner? Assessing commercial and regulatory trends in livestock & fish biotechnology. Nat Biotech 25, 47-53.
74. Murray JD, Whitelaw B and Montoliu L (2007) Meeting Report: UC Davis Transgenic Animal Research Conference VI. Transgenic Res 16, 835-837.
75. Bősze Z, Baranyi M and Whitelaw CBA (2008) Producing recombinant human proteins in the milk of livestock species. Adv Exp Med Biol. 606, 357-393.
76. Vasey DB, Wolf RC, MacArtney T, Brown K and Whitelaw CBA (2008) p21-LacZ reporter mice reflect p53-dependent toxic insult. Toxicol Appl Pharmacol 227, 440-450.
77. Strathdee D, Whitelaw CBA and Clark AJ (2008) Distal transgene insertion affects CpG island maintenance during differentiation. J Biol Chem 283, 11509-11515.
78. Whitelaw CBA, Lillico SL and King T (2008) Production of transgenic farm animals by viral-vector mediated gene transfer. Reprod Dom Anim 43 (suppl 2), 355-358.
79. Rowe J, Welsh C, Pena RN, Wolf CR, Brown K and Whitelaw CBA (2008) Illuminating role of CYP1A1 in skin. J Invest Dermat 128, 1866-1868.
80. Nelson L, Anderson S, Archibald AL, Rhind S, Condie A, Lu Z, McIntyre N, Thompson J, Nenutil R , Vojtesek B, Whitelaw CBA, Little T and Hupp T (2008) An animal model to evaluate the function and regulation of actively evolving stress protein SEP53 in oesophageal bile damage response. Cell Stress Chaperon 13, 375-385.
81. Manickam R, Pena RN and Whitelaw CBA (2008) Mammary gland differentiation inversely correlates with GDF-8 expression. Mol Reprod Dev 75, 1783-1788.
82. Whitelaw B (2008) RNA-based biotechnologies: potential future impact on animal health. OIE Bulletin 2008-2, 15-19.
83. Ritchie WA, King T, Neil C, Carlisle A, Lillico S, McLachalan G and Whitelaw CBA (2009) Transgenic sheep designed for transplantation studies. Mol Reprod Dev 76, 61-64.
84. Vasey DB, Lillico SG, Sang HM, King TJ and Whitelaw CBA (2009) CMV enhancer-promoter preferentially active in exocrine cells in vivo. Transgenic Res, 18, 309-314.
85. Capocefalo A, Fransceschi V, Whitelaw CBA, Vasey DB, Lillico SG, Cavirani S and Donofrio G (2009) p21WAF1/Cip1 as a molecular sensor for BoHV-4 replication. J Virol Meth 161, 308-311.
86. Wall R, Laible G, Mega E, Seidel Jnr G and Whitelaw B (2009) Animal productivity and genetic diversity: cloned and transgenic animals. Council for Agricultural Science and Technology Issue Paper 43 (August 2009).
87. Le Provost F, Lillico S, Passet B, Young R, Whitelaw CBA and Vilotte JL (2010) Zinc-finger nuclease systems herald new era in mammalian transgenesis. Trends Biotech 28, 134-141.
88. Fahrenkrug SC, Blake A, Carlson DF, Doran T, van Eenennaam A, Faber D, Galli C, Hackett PB, Li N, Maga EA, Murray JD, Stotish R, Sullivan E, Taylor JF, Walton M, Wheeler M, Whitelaw CBA and Glen BP (2010) Precision genetics for complex objectives in animal agriculture. J Anim Sci 88, 2530-2539.
89. Young R, Hayes JD, Brown K, Wolf CR and Whitelaw CBA (2010) Peroxiredoxin expression signatures in liver reflect toxic insult. Assay Drug Dev Technol 8, 512-517. 90. Young R, Wolf CR, Brown K, Hayes JD and Whitelaw CBA (2010) Spatial monitoring of toxicity in HMOX-LacZ transgenic mice. Transgenic Res 19, 897-902.
91. Forster R, Ancian P, Fredholm M, Simianer H and Whitelaw B (2010) The minipig as a platform for new technologies in toxicology. J Pharmacol Toxicol Meth 62, 227-235.
92. Mackenzie NCW, Lillico S, Brown K, Wolf CR and Whitelaw CBA (2010) Evaluation of RNA-knockdown strategies for modulation of cytochrome P450 reductase activity in mouse hepatocytes. J RNAi Gene Silencing 6, 416-421.
93. Vasey DB, Wolf CR, Brown K and Whitelaw CBA (2011) Spatial p21 expression profile in the mid-term mouse embryo. Transgenic Res 20, 23-28.
94. Lu Zh, DiDomenico A, Wright SH, Knight PA, Whitelaw CBA and Pemberton AD (2011) Strain-specific copy number variation in the intelectin locus on the 129 mouse chromosome 1. BMC Genomics 12:110.
95. Montoliu L and Whitelaw CBA (2011) Using standard nomenclature to adequately name transgenes, knockout gene alleles and any mutation associated to a genetically modified mouse strain. Transgenic Res. 20, 435-440.
96. Palgrave CJ, Lu Z, Lowden CS and Whitelaw CBA (2011) Light chain dynein (DYNLL1) sequence is highly conserved between pig species. Anim. Genet 42, 337.
97. Palgrave CJ, Gilmour L, Lowden CS, Lillico S, Mellencamp MA and Whitelaw CBA (2011) Species-Specific Variation in RELA Underlies Differences in NFκB Activity; A Potential Role in African Swine Fever Pathogenesis. J Virol 85, 6008-6914.
98. Pang LY, Scott M, Hayward RL, Mohammed H, Whitelaw CB, Smith GC and Hupp TR (2011) p21(waf1) is component of a positive feedback loop that maintains p53 transcriptional program. Cell Cycle 10, 932-950.
99. Lillico S, Vasey D, King T and Whitelaw B (2011) Lentiviral transgensis in livestock. Transgenic Res 20, 441-442.
100. Kolb AF, Huber RC, Lillico SG, Carlisle A, Robinson CJ, Neil C, Petri L, Sorensens DB, Olsson AS and Whitelaw CBA (2011) Milk lacking a-casein leads to permanent reduction in body size in mice. PLoS One 6(7):e21775.
101. Tong J, Lillico SG, Bi MJ, Qing T, Liu XF, Wang YY, Zheng M, Wang M, Dai YP, Whitelaw CBA and Li N (2011) Tissue-specific and expression of porcine growth hormone gene in BAC transgenic mice. Transgenic Res 20, 933-938.
102. Sartori C, DiDomenico AI, Thomson AJ, Milne E, Lillico SG, Burdon TG and Whitelaw CBA (2012) Ovine induced pluripotential stem (iPS) cells can contribute to chimeric lambs. Cell Reprog 14, 8-19.
103. Hume DA, Whitelaw CBA and Archibald AL (in press) The future of animal production: improving productivity and sustainability. J Anim Sci.
104. Vilotte JL, Chanat E, LeProvost F, Whitelaw CBA, Kolb A and Shennan DR (in press) Genetics and biosynthesis of milk, in Advanced dairy Chermistry 4th Edition, ed. P. Fox and P. McSweeney, Springer.
105. Geere HM, Argyle DJ, Corcoran BM, Whitelaw B, Milne E, Bennet D and Argyle SA (in press) Characterisation and cardiac directed differentiation of canine adult cardiac stem cells. Vet J.
106. Huber RC, Remuge L, Carlisle A, Lillico S, Sandoe P, Sorensen DB, Whitelaw CBA and Olsson AS (in press) Welfare assessment in transgenic pigs expressing green fluorescent protein (GFP). Transgenic Res.
107. Thomson AJ, Pierart H, Bogerman A, Sutherland L, Murray H, Meek S, Mountjoy E, Downing A, Talbot R, Sartori C, Whitelaw CBA Freeman TC, Archibald AL and Burdon TG (2012) Reprogramming pig foetal fibroblasts reveals a functional LIF signalling pathway. Cell Reprog 14, 112-122
108. Whitelaw CBA (in press) Transgenic Livestock for Food Production, An Introduction to. Encyclopedia of Sustainability Science and Technology, Ed. Robert Meyers, Springer.