Key References
Yadav MC, Simão AM, Narisawa S, Huesa C, McKee MD, Farquharson C, Millán JL. 2011 Loss of skeletal mineralization by the simultaneous ablation of PHOSPHO1 and alkaline phosphatase function - A unified model of the mechanisms of initiation of skeletal calcification. J Bone Miner Res. [Epub ahead of print]
Macrae VE, Davey MG, McTeir L, Narisawa S, Yadav MC, Millan JL, Farquharson C. 2010 Inhibition of PHOSPHO1 activity results in impaired skeletal mineralization during limb development of the chick. Bone 46:1146-55.
Owen HC, Roberts SJ, Ahmed SF, Farquharson C. Chondrocyte p21WAF1/CIP1 expression is increased by Dexamethasone but does not contribute to Dexamethasone-induced growth retardation in vivo. Calcified Tissue International 2009 (In Press).
Rawlinson SCF, Murray DH, Wright CDP, Mosely JR, Bredl JC, Loveridge N, Leterrier C, Constantin P, Saxon LK, Farquharson C, Pitsillides AA. Genetic selection for fast growth generates bone architecture characterised for enhanced periosteal expansion and limited consolidation of the cortices but a diminution in early responses to mechancial loading Bone. 45:357-366, 2009
Pass C, MacRae VE, Ahmed SF, Farquharson C. Inflammatory cytokines and the GH/IGF-I axis: novel actions on bone growth. Cell Biochem Funct. 27:119-27, 2009
Macrae VE, Horvat S, Pells SC, Dale H, Collinson RS, Pitsillides AA, Ahmed SF, Farquharson C. Increased bone mass, altered trabecular architecture and modified growth plate organization in the growing skeleton of SOCS2 deficient mice. J Cell Physiol 218:276-284, 2009.
Owen HC, Roberts SJ, Ahmed SF, Farquharson C Dexamethasone-induced expression of the glucocorticoids response gene lipocalin 2 in chondrocytes. Am J Physiol Endocrinol Metab. 294:E1023-34, 2008.
Roberts SJ, Narisawa S, Harmey D, Millán JL, Farquharson C Functional Involvement of PHOSPHO1 in matrix vesicle-mediated skeletal mineralization. J Bone Min Res 22:617-627, 2007.
MacRae VE, Ahmed SF, Mushtaq T, Farquharson C IGF-I signalling in bone growth: Inhibitory actions of dexamethasone and IL-1β. Growth Hormone and IGF-I Research 17:435-439, 2007.
Stewart AJ, Roberts SJ, Davey M, Seawright E, Fleming R, Farquharson C The presence of PHOSPHO1 in matrix vesicles and its developmental expression prior to skeletal mineralization. Bone 39:1000-1007, 2006.
Roberts SJ, Stewart AJ, Sadler PJ, Farquharson C. Human PHOSPHO1 displays high specific phosphoethanolamine and phosphocholine phosphatase acitivity. Biochem. J 382: 59-65, 2004.
Mushtaq T, Bijman P, Ahmed SF, Farquharson C. Insulin like growth factor-I augments chondrocyte hypertrophy and reverses glucocorticoid mediated growth retardation in fetal mice metatarsal cultures. Endocrinology 145:2478-86, 2004