References
Original Research
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2. Fell BF, FARQUHARSON C and Riddoch G. 1987 Kidney lesions in copper deficient rats. J. Comp. Pathol. 97; 187-196.
3 FARQUHARSON C and Robins SP. 1988 Female rats are susceptible to cardiac hypertrophy induced by copper deficiency: The lack of influence of estrogen and testosterone. Proc. Soc. Exp. Biol. Med. 188; 272-281.
4. Lawrence CB and FARQUHARSON C. 1988 The effects of reserpine upon the cardiac enlargement of copper deficiency. Proc. Soc. Exp. Biol. Med. 189; 173-182.
5. Scheven BAA, Hamilton N, FARQUHARSON C, Rucklidge GJ and Robins SP. 1988 Immunohistochemical localisation of native and denatured collagen types I and II in fetal and adult long bones. Bone 9; 407-414.
6. Black D, FARQUHARSON C and Robins SP. 1989 Excretion of pyridinium crosslinks of collagen in ovariectomised rats as a urinary marker for increased bone resorption. Calcified Tiss. Int. 44; 343-347.
7. FARQUHARSON C and Robins SP. 1989 Immunolocalisation of collagen types I and III in the arterial wall of the rat. Histochem J. 21; 172-178.
8. FARQUHARSON C and Robins SP. 1989 The distribution of elastin in developing and adult rat tissues using immunocytochemical techniques. J. Anat. 165; 225-236.
9. FARQUHARSON C, Duncan A and Robins SP. 1989 The effects of copper deficiency on the pyridinium crosslinks of mature collagen in the rat skeleton and cardiovascular system. Proc. Soc. Exp. Biol. Med. 192; 166-171.
10. FARQUHARSON C and Loveridge N. 1990 Cell proliferation within the growth plate of long bones assessed by bromodeoxyuridine uptake and its relationship to glucose 6-phosphate dehydrogenase activity. Bone and Mineral 10; 121-130.
11. FARQUHARSON C and Robins SP. 1991 Immunolocalisation of collagen types I, III and IV, elastin and fibronectin within the heart of normal and copper deficient rats. J. Comp. Pathol. 104; 245-255.
12.FARQUHARSON C, Whitehead CC, Rennie S, Thorp B and Loveridge N. 1992 Cell proliferation and enzyme activities associated with the development of avian tibial dyschondroplasia: an in situ biochemical study. Bone 13; 59-67.
13. FARQUHARSON C, Hesketh JE and Loveridge N. 1992 A role for the proto-oncogene c-myc in cell proliferation and differentiation: Immunocytochemical localisation within the epiphyseal growth plate. J Cell. Physiol 152; 135-144.
14. Thorp BH, Ducro B, Whitehead CC, FARQUHARSON C and Sorensen P. 1993 Avian tibial dyschondroplasia: the interaction of genetic selection and dietary 1,25-dihydroxycholecalciferol. Avian Pathol 22; 311-324.
15. FARQUHARSON C, Milne JS and Loveridge N. 1993 Mitogenic actions of insulin-like growth factor-I on human osteosarcoma MG-63 cells and rat osteoblasts maintained in situ: the role of glucose-6-phosphate dehydrogenase. Bone and Min. 22; 105-115.
16. Loveridge N, FARQUHARSON C, Hesketh JE, Whitehead CC, Jakowlew SB and Thorp BH . 1993 The control of chondrocyte differentiation during endochondral bone growth in vivo: changes in TGF-? and proto-oncogene c-myc. J. Cell Sci. 109; 949-956.
17. Thorp BH, FARQUHARSON C, Kwan APL and Loveridge 1993 Osteochondrosis/dyschondroplasia: a failure of chondrocyte differentiation. Equine Vet. J. (Suppl) 16; 13-18.
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19. Thomson BM, Dean V, FARQUHARSON C and Noble BS. 1993 Visualisation and selective elimination of a subpopulation of mitogen-responsive bone marrow stromal cells using bromodeoxyuridine and photo-induced killing Bone 14; 779-786.
20. FARQUHARSON C, Whitehead CC and Loveridge N. 1994 Alterations in glycosaminoglycan concentration and sulphation during chondrocyte maturation. Calcif. Tissue Int. 54; 296-303.
21. FARQUHARSON C and Whitehead C. 1995 Differentiation and mineralization in chick chondrocytes maintained in high cell density culture: A model for endochondral ossification. In Vitro Cell Dev Biol 31:288-294.
22. Rennie JS, McCormack HA, FARQUHARSON C, Berry JL, Mawer EB and Whitehead CC. 1995 Interaction between dietary 1,25-dihydroxycholecalciferol and calcium and effects on management on the occurrence of tibial dyschondroplasia, leg abnormalities in broiler chickens. Brit. Poultry Sci. 36:465-477.
23. Loveridge N, FARQUHARSON C, Palmer R, Lobley GE and Flint DJ. 1995 Growth hormone and longitudinal bone growth in vivo: short-term effect of a growth hormone antiserum. J. Endocrinol. 146:55-62.
24. FARQUHARSON C, Berry JL, Mawer EB, Seawright E and Whitehead CC. 1996 Regulators of chondrocyte differentiation in tibial dyschondroplasia. An in vivo and in vitro study. Bone 17: 279-286.
25. FARQUHARSON C, Rennie JS, Loveridge N and Whitehead CC. 1996 In vivo and in vitro effect of 1,25-dihydroxyvitamin D3 and 1,25-dihydroxy-16-ene-23-yne-vitamin D3 on the proliferation and differentiation of avian chondrocytes: their role in tibial dyschondroplasia. J Endocrinol 148:465-474
26 FARQUHARSON C, Law AS, Seawright E, Burt DW and Whitehead CC. 1996 The expression of transforming growth factor-b by cultured chick growth plate chondrocytes: Differential regulation by 1,25-dihydroxyvitmain D3 J Endocrionol 149: 277-285.
27 FARQUHARSON C, Duncan A, Seawright E, Whitehead CC and Robins SP. 1996 Distribution and quantification of pyridinium crosslinks of collagen within the different maturational zones of the chick growth plate. Biochim. Biophys. Acta 1290:250-256.
28 Berry JL, FARQUHARSON C, Whitehead CC and Mawer EB. 1996 Growth plate chondrocyte vitamin D receptor number and affinity are reduced in avian tibial dyschondroplasia. Bone 19: 197-203.
29 Maxwell MH, Robertson GW and FARQUHARSON C. 1996 Evidence of ultracytochemical mitochondrial-derived hydrogen peroxide activity in myocardial cells from broiler chickens with ascites syndrome. Res. Vet. Sci 61: 7-12.
30 Rucklidge GJ, Milne G, Bos KJ, FARQUHARSON C and Robins SP 1997 Deer antler does not represent a typical endochondral growth system: immunodetection of collagen type X but little type II in growing antler tissue. Comp. Biochem. and Physiol. B-Biochem. & Mol. Biol. 118:303-308.
31 Ohyama K, FARQUHARSON C, Whitehead CC and Shapiro IM. 1997 Further observations on programmed cell death in the epiphyseal growth plate: Comparison of normal and dyschondroplastic epiphyses. J. Bone Min. Res. 12:1647-1656.
32 FARQUHARSON C, Berry JL, Mawer EB, Seawright E and Whitehead CC. 1998 Ascorbic acid-induced chondrocyte differentiation: the role of the extracellular matrix and 1,25-dihydroxyvitamin D. Eur. J. Cell Biol. 76:110-118.
33 Jefferies D, Botman M, FARQUHARSON C, Lester D, Whitehead CC, Thorp BH, Houston B 1998 Cloning differentially regulated genes from chondrocytes using agarose gel differential display. Biochim. Biophys. Acta 1396:237-241.
34 Houston B, Seawright E, Jefferies D, Hoogland E, Lester D, Whitehead CC, and FARQUHARSON C. 1998 Identification and cloning of a novel phosphatase expressed at high levels in differentiating growth plate chondrocytes. Biochim. Biophys. Acta 1448:500-506.
35 Lester D, FARQUHARSON C, Paton R, Seawright E, Jefferies D, Burt D and Houston B. 1999 A novel integral membrane protein is differentially expressed in the chick growth plate and maps to chromosome 1. Animal Genetics 30:300-303.
36 FARQUHARSON C, Lester D, Seawright E, Jefferies D and Houston B. 1999 Microtubules are potential regulators of growth plate chondrocyte differentiation and hypertrophy. Bone 25: 405-412.
37 Williams B, Solomon S, Waddington D, Thorp BH and FARQUHARSON C 2000 Skeletal development in the meat-type chicken. Brit. Poultry Sci. 41:141-149.
38 Cermelli S, Zerega B, Carlevaro M, Gentili C, Thorp B, FARQUHARSON C, Cancedda R and Descalzi F. 2000 Ex-FABP, a lipocalin developmentally regulated in chick embryo, is expressed in inflammation and modulated by inflammatory-antiinflammatory agents: physiological acute responses in endochondral bone formation and other differentiation pathways. Eur. J. Cell Biol. 79:155-164
39 Jefferies D, Botman M, Lester D, Whitehead CC, Thorp BH, Houston B and FARQUHARSON C 2000 Expression patterns of chondrocyte genes cloned by differential display in tibial dyschondroplasia. Biochim. Biophys. Acta 1501: 180-188.
40 Lester D, FARQUHARSON C, Russell G, Houston, B. 2000 Identification of a family of non-canonical ubiquitin conjugating enzymes structurally related to yeast UBC6. Biochim. Biophys. Acta. 269: 474-480
41 Williams B, Waddington D, Solomon S, FARQUHARSON C. 2000 Dietary effects on bone quality and turnover, and Ca and P metabolism in chickens. Res. Vet. Sci 69: 81-87
42 FARQUHARSON C, Seawright E and Jefferies D 2001 Parathyroid hormone related-peptide expression in tibial dyschondroplasia. Avian Pathol 30:327-335.
43 FARQUHARSON C, Jefferies D, Seawright E, Houston B. 2001 Regulation of chondrocyte terminal differentiation in the post embryonic growth plate: The role of the PTHrP-Indian hedgehog axis. Endocrinology 142: 4131-4140.
44 Jefferies D, FARQUHARSON C, Thompson J,. Smith W, Seawright E, McCormack H, Whitehead CC. 2002 Differences in metabolic parameters and gene expression related to degenerative joint disease in pigs fed 25-hydroxyvitamin Veterinary Pathology. Vet. Res 33: 383-396.
45 Mushtaq T, FARQUHARSON C, Seawright E, Ahmed SF. 2002. Glucocorticoid effects on chondrogenesis, differentiation and apoptosis in the murine ATDC5 cell line. J Endocrinol. 175:705-13.
46 Houston B, Paton IR, Burt DW, FARQUHARSON C. 2002. Chromosomal localization of the chicken and mammalian orthologues of the orphan phosphatase PHOSPHO1 gene. Anim. Genet. 33(6):451-4.
47 Jefferies D and FARQUHARSON C. 2002. Effects of choice of reverse-transcriptase enzyme and use of T4 gene 32 protein on banding patterns in agarose gel differential display. Anal. Biochem. 308: 192-194
48 Webster SV, FARQUHARSON C , Jefferies D and Kwan APL. 2003 Expression of type X collagen, Indian hedgehog and parathyroid hormone-related protein in normal and tibial dyschondroplastic chick growth plates. Avian pathology 32: 69-80.
49 Stewart, A. J., Schmid, R., Blindauer, C. A., Paisley, S. J., FARQUHARSON, C. 2003
Comparative modelling of human PHOSPHO1 reveals a new group of phosphatases within the HAD superfamily. Protein Engineering 16:889-895.
50 Williams B, Waddington D, Murray DH, FARQUHARSON C. 2004 Bone strength during growth: influence of growth rate on cortical porosity and mineralisation. Calcified Tissue Int 74: 236-245.
51 Houston, B., Stewart, A. J., FARQUHARSON, C. PHOSPHO1 - A novel phosphotase specifically expressed at sites of mineralization in bone and cartilage. Bone. 2004; 34:629-637.
52 Mushtaq T, Bijman P, Ahmed SF, FARQUHARSON C. Insulin like growth factor-I augments chondrocyte hypertrophy and reverses glucocorticoid mediated growth retardation in fetal mice metatarsal cultures. Endocrinology. 2004;145:2478-86.
53. Roberts SJ, Stewart AJ, Sadler PJ, FARQUHARSON C. Human PHOSPHO1 displays high specific phosphoethanolamine and phosphocholine phosphatase acitivity. Biochem. J 382: 59-65, 2004.
54. Stewart A. J., Mukherjee J., Roberts S. J., Lester D. and FARQUHARSON C. Identification of a novel class of mammalian phosphoinositol-specific phospholipase C enzymes. Int. J. Mol. Med. 2005; 15: 117-121, 2005.
55. Roberts S.J., Stewart A.J., Schmid R., Blindauer C.A., Bond S.R., Sadler P.J., Farquharson C. (2005) Probing the substrate specificities of human PHOSPHO1 and PHOSPHO2. Biochim. et Biophys. Acta 1752, 73-82.
56. MaCrae V, Farquharson C, Ahmed SF. (2006) The Restricted Potential For Recovery Of Growth Plate Chondrogenesis And Longitudinal Bone Growth Following Exposure To Pro-inflammatory Cytokines. J Endocrinology 189: 319-328.
57. Stewart AJ, Houston B, Farquharson C (2006). Elevated expression of hypoxia inducible factor-2α in terminally differentiating growth plate chondrocytes J Cell Physiology 206:435-440.
58. Stewart AJ, Roberts SJ, Davey M, Seawright E, Fleming R, Farquharson C (2006) The presence of PHOSPHO1 in matrix vesicles and its developmental expression prior to skeletal mineralization. Bone 39:1000-1007
59. MacRae VE, Burdon T, Ahmed SF, Farquharson C (2006). Ceramide inhibition of chondrocytes proliferation and bone growth is IGF-I independent. J Endocrinology 191:369-377
60. Owen H, Miner JN, Ahmed SF, Farquharson C. 2007 The Growth Plate Sparing Effects of the Selective Glucocorticoid Receptor Modulator, AL-438. Mol Cell Endocrinology 264:164-170
61. MacRae VE, Wong SC, Smith W, Gracie A, McInnes I, Galea P, Gardner-Medwin J, Farquharson C, Ahmed SF. 2007 Cytokine profiling and in vitro studies of murine bone growth using biological fluids from children with juvenile idiopathic arthritis. Clin. Endocrinol 67:442-448.
62. Roberts SJ, Narisawa S, Harmey D, Millán JL, Farquharson C 2007 Functional Involvement of PHOSPHO1 in Matrix Vesicle-Mediated Skeletal Mineralization. J Bone Min Res 22:617-627.
63. MacRae VE, Ahmed SF, Mushtaq T, Farquharson C 2007 IGF-I signalling in bone growth: Inhibitory actions of dexamethasone and IL-1β. Growth Hormone and IGF-I Research 17:435-439.
64. Roberts SJ, Owen HC, Farquharson C 2008 Identification of a novel splice variant of the haloacid dehalogenase - PHOSPHO1. Biochem. Biophys. Res. Comm. 371. 872-876.
65. Owen HC, Roberts SJ, Ahmed SF, Farquharson C 2008 Dexamethasone-induced expression of the glucocorticoids response gene lipocalin 2 in chondrocytes. Am J Physiol Endocrinol Metab. 294:E1023-34.
66. MacRae VE, Horvat S, Pells S, Dale, H Collinson RS, Pitsillides AA, Ahmed SF, Farquharson C. 2009 Increased bone mass, altered trabecular architecture and modified growth plate organization in the growing skeleton of SOCS2 deficient mice. J Cell Physiol 218:276-284
67. Rawlinson SCF, Murray DH, Wright CDP, Mosely JR, Bredl JC, Loveridge N, Leterrier C, Constantin P, Saxon LK, Farquharson C, Pitsillides AA. 2009. Genetic selection for fast growth generates bone architecture characterised for enhanced periosteal expansion and limited consolidation of the cortices but a diminution in early responses to mechancial loading Bone. 45:357-366.
68. Owen HC, Roberts SJ, Ahmed SF, Farquharson C. 2009. Chondrocyte p21WAF1/CIP1 expression is increased by Dexamethasone but does not contribute to Dexamethasone-induced growth retardation in vivo. Calcif. Tiss. Int. 85:326-334.
69. Macrae VE, Davey MG, McTeir L, Narisawa S, Yadav MC, Millan JL, Farquharson C. 2010 Inhibition of PHOSPHO1 activity results in impaired skeletal mineralization during limb development of the chick. Bone 46:1146-55.
70. Ciancaglini P, Yadav MC, Sper Simão AM, Narisawa S, Pizauro JM, Farquharson C, Hoylaerts MF, Millán JL. 2010 Kinetic Analysis of Substrate Utilization by Native and TNAP-, NPP1- or PHOSPHO1-Deficient Matrix Vesicles. J Bone Miner Res 25:716-23.
71. Loqman MY, Bush PG, Farquharso, C, Hall AC 2010. A cell shrinkage artefact in growth plate chondrocytes with common fixative solutions: Importance of fixative osmoratlity for maintaining morphology. European Cells and Materials 19: 214-227.
72. Yadav MC, Simão AM, Narisawa S, Huesa C, McKee MD, Farquharson C, Millán JL. 2011 Loss of skeletal mineralization by the simultaneous ablation of PHOSPHO1 and alkaline phosphatase function - A unified model of the mechanisms of initiation of skeletal calcification. J Bone Miner Res. 26:286-297.
73. Huesa C, Yadav MC, Finnilä MAJ, Goodyear SR, Robins SP, Tanner KE, Aspden RM, Millán JL and Farquharson C. 2011. PHOSPHO1 is essential for mechanically competent mineralization and the avoidance of spontaneous fractures. Bone 48:1066-74.
74. Zhu D, Mackenzie NCW, Millán JL, Farquharson C, MacRae VE. 2011. The Appearance and Modulation of Osteocyte Marker Expression During Calcification of Vascular Smooth Muscle Cells. PLOS One 6:e19595
75. Yang S, Wang Z, Farquharson C, Alkasir R, Zahra M, Ren G, Han B. 2011. Sodium fluoride induces apoptosis and alters bcl-2 family protein expression in MC3T3-E1 osteoblastic cells. Biochem Biophys Res Commun 410: 910-915
76. Yang JH, Hou JF, Farquharson C, Zhou ZL, Deng YF, Wang L, Yu Y. (2011). Localisation and expression of TRPV6 in all intestinal segments and kidney of laying hens. British Poultry Science 52(4): 507-516.
77. Pass C, Macrae VE, Huesa C, Ahmed SF. & Farquharson C. (2012). SOCS2 is the critical regulator of GH action in murine growth plate chondrogenesis. Journal of Bone and Mineral Research E-pub 10 January.
78. Mackenzie NCW, Zhu D, Milne EM, van 't Hof R, Martin A, Quarles DL, Millán JL, Farquharson C. & MacRae VE. (2012). Altered Bone Development and an Increase in FGF-23 Expression in Enpp1-/- Mice. PLoS One, 7(2), e32177.
Reviews and Book Chapters
1. Loveridge N, FARQUHARSON C and Scheven BAA. 1990 Endogenous mediators of growth. Proc. Nutr. Soc. 49; 33-40.
2. Loveridge N, Thomson BM and FARQUHARSON C. 1992 Bone growth and turnover. In : Bone Biology and Skeletal Disorders in Poultry. CC Whitehead (ed), pp 3-18, Carfax Publishing Co, Oxfordshire, England.
2. Loveridge N and FARQUHARSON C. 1993 Growth plate chondrocytes in situ: Studies on proliferation and differentiation . Acta. Pediat. 391; 42-48.
3. Robins SP and FARQUHARSON C. 1995 Connective tissue proteins of blood vessel wall in health and disease. In: VaScular Pathology (Stehbens WE and Lie JT eds) , pp 88-127, Chapman and Hall, London.
4. Williams B, Waddington D and FARQUHARSON C. 1999 The influence of dietary calcium and phosphorus on skeletal quality of the modern broiler chicken. In: Calcium Metabolism: Comparative Endocrinology (Dacke C, Danks J, Flik G, Gay C eds), pp 81-86, BioScientifica Ltd, Bristol
5. FARQUHARSON C and Jefferies D 2000 Chondrocytes and longitudinal bone growth: The development of tibial dyschondroplasia. Poultry Sci. 79:994-1004.
6. FARQUHARSON C 2002 Tibial dyschondroplasia: A growth plate abnormality caused by delayed terminal differentiation. In ‘The growth plate’ Shapiro IM, Boyan B, Anderson HC, Eds) pp 201- 211, IOS Press Amsterdam.
7. FARQUHARSON C 2003. Bone Growth. Biology of Growth of Domestic Animals (Scanes C, ed) pp 170-185., Iowa State University Press/Blackwell
8. MacRae V, Farquharson C, Ahmed SF. (2006) The pathophysiology of the growth plate in juvenile idiopathic arthritis. Rheumatology 45:11-19.
9. MacRae VE, Wong SC; Farquharson C, Ahmed SF. 2006 Cytokine actions in growth disorders associated with pediatric chronic inflammatory diseases. Int J Mol Med 18: 1011-1018
10. Stewart AJ, Morgan K, Farquharson C, Millar RP (2007) Phospholipase C-eta enzymes as putative protein kinase C and Ca2+ signalling components in neuronal and neuroendocrine tissues. Neoroendocrinology 86:243-248.
11. Perry RJ, Farquharson C, Ahmed SF (2008) The role of sex steroids in controlling pubertal growth Clinical Endocrinology 68:4-15.
12. Pass C, MacRae VE, Ahmed SF Farquharson C 2009 Inflammatory cytokines and the GH/IGF-I axis: novel actions on bone growth. Cell Biochem Function 27: 119-127.
13. Ahmed SF and Farquharson C 2010 The effect of GH and IGF1 on linear growth and skeletal development and their modulation by SOCS proteins. J Endocrinol. 206:249-59.
14. Farquharson, C. (2011). Social networking between cells of the foetal skeleton: the importance of thyroid hormones. Journal of Endocrinology 210(2): 135-136.
15. Farquharson, C. and K. Staines (2011). The skeleton: no bones about it. Journal of Endocrinology e-pub 26 July