Publications
• Pang LY, Bergkvist GT, Cervantes-Arias A, Yool DA, Muirhead R, Argyle DJ. Identification of tumour initiating cells in feline head and neck squamous cell carcinoma and evidence for gefitinib induced epithelial to mesenchymal transition. Veterinary Journal 2012 E-pub 16 February.
•Goldfinch N & Argyle D. Feline lung-digit syndrome: Unusual metastatic patterns of primary lung tumours in cats. Journal of Feline Medicine and Surgery 2012 14(3): 202-208.
•Cervantes-Arias A, Pang LY & Argyle DJ. Epithelial-mesenchymal transition as a fundamental mechanism underlying the cancer phenotype. Veterinary and Comparative Oncology 2012 E-pub 7 March.
•Brydges NM, Argyle DJ, Mosley JR, Duncan JC, Fleetwood-Walker S & Clements DN. Clinical assessments of increased sensory sensitivity in dogs with cranial cruciate ligament rupture. Veterinary Journal 2012 E-pub 1 March.
• Argyle D. Veterinary and Comparative Oncology [Editorial], A decade in cancer research. Veterinary and Comparative Oncology 2012 10(1): 1.
• Hodgkiss-Geere HM, Argyle DJ, Corcoran BM, Whitelaw B, Milne E, Bennett D, Argyle, SA Characterisation and cardiac directed differentiation of canine adult cardiac stem cells. Veterinary Journal 2012 191(2): 176-182.
• Gattegno-Ho D, Argyle SA, Argyle DJ. Stem cells and veterinary medicine: Tools to understand disease and enable tissue regeneration and drug discovery. Veterinary Journal 2012 191(1): 19-27.
• Bergkvist GT, Argyle DJ, Morrison L, MacIntyre N, Hayes A, Yool DA. Expression of epidermal growth factor receptor (EGFR) and Ki67 in feline oral squamous cell carcinomas (FOSCC). Veterinary and Comparative Oncology 2011 9(2): 106-117.
• Bergkvist GT, Argyle DJ, Pang LY, Muirhead R, Yool DA. Studies on the inhibition of feline EGFR in squamous cell carcinoma: Enhancement of radiosensitivity and rescue of resistance to small molecule inhibitors." Cancer Biology & Therapy 2011 11(11): 927-937.
• Blacking TM, Waterfall M, Argyle D. CD44 is associated with proliferation, rather than a specific cancer stem cell population, in cultured canine cancer cells. Veterinary Immunology and Immunopathology 2011 141(1-2): 46-57.
• Elders RC, Holder A, Baines SJ, Argyle D, Catchpole B. Targeted knockdown of canine KIT (stem cell factor receptor) using RNA interference." Veterinary Immunology and Immunopathology 2011 141(1-2): 151-156.
• Hodgkiss-Geere HM, Argyle DJ, Corcoran BM, Whitelaw B, Milne E, Bennett D,
Argyle SA. Cardiac Specific Gene Expression Changes in Long Term Culture of Murine Mesenchymal Stem Cells. International Journal of Stem Cells 2011. 4(2): 143-148.
• Lynch S, Savary-Bataille K. Leeuw B, Argyle DJ. Development of a questionnaire assessing health-related quality-of-life in dogs and cats with cancer. Veterinary and Comparative Oncology 2011. 9(3): 172-182.
• Thomas R, Seiser EL, Motsinger-Reif A, Borst L, Valli VE, Kelley K, Suter SE, Argyle D,
Burgess K, Bell J, Lindblad-Toh K, Modiano JF, Breen M. Refining tumor-associated aneuploidy through 'genomic recoding' of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas. Leukemia & Lymphoma 2011 52(7): 1321-1335.
• Argyle D. Ensuring a future for clinical research. Veterinary Record 2010 167(24): 944-945.
• Pang, L. Y. and D. J. Argyle. Cancer stem cells and telomerase as potential biomarkers in veterinary oncology. Veterinary Journal 2010 185(1): 15-22.
•Argyle DJ and DM Vail. Medline acceptance and impact factor assignment. Vet Comp Oncol 2009 7(3): 151-152.
• Pang LY and DJ Argyle. Using naturally occurring tumours in dogs and cats to study telomerase and cancer stem cell biology." Biochim Biophys Acta 2009 1792(4): 380-391.
• Penzo C, Ross M, Muirhead R, Else R, Argyle DJ. Effect of recombinant feline interferon- w alone and in combination with chemotherapeutic agents on putative tumour-initiating cells and daughter cells derived from canine and feline mammary tumours. Veterinary and Comparative Oncology 2009 7(4): 222-229.
• Argyle DJ and SA Argyle. Stem cells and animal cloning - the impact on companion animal medicine. European Journal of Companion Animal Practice 2008 18(1): 85-93.
• Argyle DJ. Prostate cancer in dogs and men: A unique opportunity to study the disease. Vet J. 2009 180: 137-138
• Mellor PJ, Haugland S, Smith KC, Powell RM, Archer J, Scase TJ, Villiers EJ, McNeil PE, Nixon C, Knott C, Fournier D, Murphy S, Polton GA, Belford C, Philbey AW, Argyle DJ, Herrtage ME, Day MJ. Histopathologic, immunohistochemical, and cytologic analysis of feline myeloma-related disorders: further evidence for primary extramedullary development in the cat. Vet Pathol. 2008 Mar;45(2):159-73.
• Lund JR, Paoloni M, Kurzman I, Padilla M, Argyle DJ. Inhibition of canine telomerase in vitro and in vivo using RNAi: further development of a natural canine model for telomerase-based cancer therapies. Vet J. 2008 Aug;177(2):192-197. Epub 2007 Nov 5.
• Moffett J and D Argyle. Companion animals and 'the big C'. Irish Veterinary Journal. 2008 6: 6.
• Wilson H, Huelsmeyer M, Chun R, Young KM, Friedrichs K, Argyle DJ. Isolation and characterisation of cancer stem cells from canine osteosarcoma. Vet J. 2008 Jan;175(1):69-75. Epub 2007 Sep 11.
• Argyle DJ. Telomerase: A missing link between ageing, cancer and novel therapies? Vet J. 2008 Feb;175(2):149-50. Epub 2007 Apr 18.
• Campbell SE, Nasir L, Gault EA, Argyle DJ, Bennett D. Preliminary studies of particle-mediated gene delivery to the joints of dogs. Vet Rec. 2007 Apr 7;160(14):476-81.
• Mellor PJ, Haugland S, Murphy S, Smith KC, Holloway A, Archer J, Powell RM, Polton GA, Tasker S, McCormick D, Tempest ME, McNeil PE, Scase TJ, Knott CD, Bonfanti U, Villiers EJ, Argyle DJ, Herrtage ME, Day MJ. Myeloma-related disorders in cats commonly present as extramedullary neoplasms in contrast to myeloma in human patients: 24 cases with clinical follow-up. J Vet Intern Med. 2006 Nov-Dec;20(6):1376-83.
• Long S, Argyle DJ, Nixon C, Nicholson I, Botteron C, Olby N, Platt S, Smith K, Rutteman GR, Grinwis GC, Nasir L. Telomerase reverse transcriptase (TERT) expression and proliferation in canine brain tumours. Neuropathol Appl Neurobiol. 2006 Dec;32(6):662-73.
• Mellor PJ, Polton GA, Brearley M, Haugland S, Smith KC, Scase TJ, McNeil PE, Holloway A, Archer J, Powell RM, Villiers EJ, Herrtage ME, Argyle DJ, Day MJ. Solitary plasmacytoma of bone in two successfully treated cats. J Feline Med Surg. 2007 Feb;9(1):72-7. Epub 2006 Aug 2.
• Knottenbelt C, Mellor D, Nixon C, Thompson H, Argyle DJ. Cohort study of COX-1 and COX-2 expression in canine rectal and bladder tumours. J Small Anim Pract. 2006 Apr;47(4):196-200.
• Knottenbelt C, Chambers G, Gault E, Argyle DJ. The in vitro effects of piroxicam and meloxicam on canine cell lines. J Small Anim Pract. 2006 Jan;47(1):14-20.
• Muir P, Danova NA, Argyle DJ, Manley PA, Hao Z. Collagenolytic protease expression in cranial cruciate ligament and stifle synovial fluid in dogs with cranial cruciate ligament rupture. Vet Surg. 2005 Sep-Oct;34(5):482-90.
• Argyle DJ. The benefits of comparative medicine -- a hundred years to come to our senses. Vet J. 2005 Sep;170(2):147-8.
• Long S, Argyle DJ, Gault EA, Campbell S, Nasir L. The canine telomerase catalytic subunit (dogTERT): characterisation of the gene promoter and identification of proximal core sequences necessary for specific transcriptional activity in canine telomerase positive cell lines. Gene. 2005 Sep 26;358:111-20.
• O'Donovan LH, McMonagle EL, Taylor S, Bain D, Pacitti AM, Golder MC, McDonald M, Hanlon L, Onions DE, Argyle DJ, Jarrett O, Nicolson L. A vector expressing feline mature IL-18 fused to IL-1beta antagonist protein signal sequence is an effective adjuvant to a DNA vaccine for feline leukaemia virus. Vaccine. 2005 May 31;23(29):3814-23. Epub 2005 Mar 16.
• Nixon C, Chambers G, Ellsmore V, Campo MS, Burr P, Argyle DJ, Reid SW, Nasir L. Expression of cell cycle associated proteins cyclin A, CDK-2, p27kip1 and p53 in equine sarcoids. Cancer Lett. 2005 Apr 28;221(2):237-45.
• Campbell SE, Bennett D, Nasir L, Gault EA, Argyle DJ. Disease- and cell-type-specific transcriptional targeting of vectors for osteoarthritis gene therapy: further development of a clinical canine model. Rheumatology (Oxford). 2005 Jun;44(6):735-43. Epub 2005 Mar 9.
• O'Donovan LH, McMonagle EL, Taylor S, Argyle DJ, Nicolson L. Bioactivity and secretion of interleukin-18 (IL-18) generated by equine and feline IL-18 expression constructs. Vet Immunol Immunopathol. 2004 Dec 28;102(4):421-8.
• Nasir L, Gault E, Campbell S, Veeramalai M, Gilbert D, McFarlane R, Munro A, Argyle DJ. Isolation and expression of the reverse transcriptase component of the Canis familiaris telomerase ribonucleoprotein (dogTERT). Gene. 2004 Jul 7;336(1):105-13.
• Blackwood L, Argyle DJ. The activity of the feline thyroglobulin promoter is compromised by flanking adenoviral sequence. Vet J. 2004 Jul;168(1):50-9.
• McKevitt TP, Nasir L, Wallis CV, Argyle DJ. A cohort study of telomere and telomerase biology in cats. Am J Vet Res. 2003 Dec;64(12):1496-9.
• Cave TA, Martineau H, Dickie A, Thompson H, Argyle DJ. Idiopathic hepatic veno-occlusive disease causing Budd-Chiari-like syndrome in a cat. J Small Anim Pract. 2002 Sep;43(9):411-5.
• McKevitt TP, Nasir L, Devlin P, Argyle DJ. Telomere lengths in dogs decrease with increasing donor age. J Nutr. 2002 Jun;132(6 Suppl 2):1604S-6S.
• Campbell SE, Sood A, Argyle DJ, Nasir L, Argyle SA, Bennett D. The cloning and functional analysis of canine matrix metalloproteinase-13 gene promoter. Gene. 2002 Mar 20;286(2):233-40.
• Cave TA, Hine R, Howie F, Thompson H, Argyle DJ. Uterine carcinoma in a 10-month-old golden retriever. J Small Anim Pract. 2002 Mar;43(3):133-5.
• Schijns VE, Scholtes NC, Zuilekom HI, Sanders LE, Nicolson L, Argyle DJ. Facilitation of antibody forming responses to viral vaccine antigens in young cats by recombinant baculovirus-expressed feline IFN-gamma. Vaccine. 2002 Mar 15;20(13-14):1718-24.
• McMonagle EL, Taylor S, van Zuilekom H, Sanders L, Scholtes N, Keanie LJ, Hopkins CA, Logan NA, Bain D, Argyle DJ, Onions DE, Schijns VE, Nicolson L. Production of biologically active equine interleukin 12 through expression of p35, p40 and single chain IL-12 in mammalian and baculovirus expression systems. Equine Vet J. 2001 Nov;33(7):693-8.
• Nasir L, Rutteman GR, Reid SW, Schulze C, Argyle DJ. Analysis of p53 mutational events and MDM2 amplification in canine soft-tissue sarcomas. Cancer Lett. 2001 Dec 10;174(1):83-9.
• Nasir L, Devlin P, Mckevitt T, Rutteman G, Argyle DJ. Telomere lengths and telomerase activity in dog tissues: a potential model system to study human telomere and telomerase biology. Neoplasia. 2001 Jul-Aug;3(4):351-9.
• Campbell SE, Nasir L, Argyle DJ, Bennett D. Molecular cloning and characterization of canine metalloproteinase-9 gene promoter. Gene. 2001 Jul 25;273(1):81-7.
• Blackwood L, Onions DE, Argyle DJ. Characterization of the feline thyroglobulin promoter. Domest Anim Endocrinol. 2001 Apr;20(3):185-201.
• Blackwood L, O'Shaughnessy PJ, Reid SW, Argyle DJ. E. coli nitroreductase/CB1954: in vitro studies into a potential system for feline cancer gene therapy. Vet J. 2001 May;161(3):269-79.
• Campbell SE, Nasir L, Argyle DJ, Gault EA, Duthie S, Bennett D. Cloning of canine IL-1ra, TNFR and TIMP-2. Vet Immunol Immunopathol. 2001 Jan 26;78(2):207-14.
• Taylor S, Hanlon L, McGillivray C, Gault EA, Argyle DJ, Onions DE, Nicolson L. Cloning and sequencing of feline and canine ice-related cDNAs encoding hybrid caspase-1/caspase-13-like propeptides. DNA Seq. 2000;10(6):387-94.
• Nasir L, Krasner H, Argyle DJ, Williams A. Immunocytochemical analysis of the tumour suppressor protein (p53) in feline neoplasia. Cancer Lett. 2000 Jul 3;155(1):1-7.
• Nasir L, Burr PD, McFarlane ST, Gault E, Thompson H, Argyle DJ. Cloning, sequence analysis and expression of the cDNAs encoding the canine and equine homologues of the mouse double minute 2 (mdm2) proto-oncogene. Cancer Lett. 2000 Apr 28;152(1):9-13.
• Nicolson L, Penha-Goncalves MN, Keanie JL, Logan NA, Argyle DJ, Onions DE. Cloning and sequencing of horse interleukin-12 and interleukin-18 cDNAs. Immunogenetics. 1999 Oct;50(1-2):94-7.
• Burr PD, Argyle DJ, Reid SW, Nasir L. Nucleotide sequence of the porcine p53 cDNA, and the detection of recombinant porcine p53 expressed in vitro with a variety of anti-p53 antibodies. Oncogene. 1999 Sep 2;18(35):5005-9.
• Nasir L, Argyle DJ. Mutational analysis of the tumour suppressor gene p53 in lymphosarcoma in two bull mastiffs. Vet Rec. 1999 Jul 3;145(1):23-4.
• Argyle DJ, McGillivery C, Nicolson L, Onions DE. Cloning, sequencing, and characterization of dog interleukin-18. Immunogenetics. 1999 Jun;49(6):541-3.
• Wardlow S, Penha-Goncalves MN, Argyle DJ, Onions DE, Nicolson L. Nucleotide sequence of equine caspase-1 cDNA. DNA Seq. 1999;10(2):133-7.
• Argyle DJ, Harris M, Lawrence C, McBride K, Barron R, McGillivray C, Onions DE. Expression of feline recombinant interferon-gamma in baculovirus and demonstration of biological activity. Vet Immunol Immunopathol. 1998 Jul 8;64(2):97-105.
• Nasir L, Argyle DJ, McFarlane ST, Reid SW. Nucleotide sequence of a highly conserved region of the canine p53 tumour suppressor gene. DNA Seq. 1997;8(1-2):83-6.
• Dunham SP, Argyle DJ, Onions DE. The isolation and sequence of canine interleukin-2. DNA Seq. 1995;5(3):177-80.
• Argyle DJ, Smith K, McBride K, Fulton R, Onions DE. Nucleotide and predicted peptide sequence of feline interferon-gamma (IFN-gamma). DNA Seq. 1995;5(3):169-71.
• Curran JA, Argyle DJ, Cox P, Onions DE, Nicolson L. Nucleotide sequence of the equine interferon gamma cDNA. DNA Seq. 1994;4(6):405-7.
Reviews
• Argyle DJ, Blacking T. From viruses to cancer stem cells: dissecting the pathways to malignancy. Vet J. 2008 Sep;177(3):311-23. Epub 2007 Nov 19.
• Argyle DJ, Nasir L. Telomerase: a potential diagnostic and therapeutic tool in canine oncology. Vet Pathol. 2003 Jan;40(1):1-7.
• Blackwood L, Argyle DJ. Feline hyperthyroidism: advances towards novel molecular therapeutics. J Small Anim Pract. 2002 Feb;43(2):58-66.
• Argyle DJ. Gene therapy in veterinary medicine. Vet Rec. 1999 Apr 3;144(14):369-76.