Full Reference List
Refereed Publications
1976
• Hume D.A. & Weidemann, M.J. (1976) Hormonal regulation of gluconeogenesis in isolated rat hepatocytes: An undergraduate class experiment. Biochemical Education 4:13-15
1977
• Yasmeen, D., Laird, A.J., Hume, D.A. & Weidemann, M.J. (1977) Activation of 3-O-methyl glucose transport in rat thymus lymphocytes by concanavalin A. Temperature and calcium ion dependence and sensitivity to puromycin but not to cycloheximide. Biochim. Biophys. Acta 500:89-102
• Hume, D.A. & Weidemann, M.J. (1977) Mitogenic stimulation of thymocyte glucose transport alters the sensitivity of the glucose carrier to N-ethyl-maleimide and phloretin. Hoppe-Seyler. Z. Physiol. Chem. 358:122-124
1978
• Hume, D.A. & Weidemann, M.J. (1978) On the stimulation of rat thymocyte glucose transport by mitogenic stimuli. J. Cell. Physiol. 96: 303-307
• Hume, D.A. & Weidemann, M.J. (1978) Effect of NH4+ and Ca2+ on gluconeogenesis from lactate in isolated rat hepatocytes. Hormone Metab. Res. 10:449-450
• Hume, D.A., Vijayakumar, E.K., Schweinberger, F., Russell, L.M. & Weidemann, M.J. (1978) On the role of calcium in the regulation of rat thymocyte pyruvate oxidation by mitogens. Biochem. J. 174:711-716
• Hume, D.A., Radik, J.L., Ferber, E. & Weidemann, M.J. (1978) Aerobic glycolysis and lymphocyte transformation. Biochem. J. 174: 703-709
• Hume, D.A., Hansen, K., Weidemann, M.J & Ferber, E. (1978) Cytochalasin B inhibits lymphocyte transformation through its effects on glucose transport.Nature 272: 359
1979
• Hume, D.A., Weidemann, M.J. & Ferber, E. (1979) Quercetin preferentially inhibits mitogen-stimulated thymocyte glucose transport. J. Natl. Cancer Inst. 62:1243-1249
• Hume, D.A., Thornton, M.R., Weidemann, M.J. & Speth, V. (1979) Rapid alterations in cellular morphology induced in rat thymocytes by mitogenic stimuli. J. Cell. Physiol. 101:523-530
1981
• Hume, D.A., Wroggeman, K., Ferber, E., Kolbuch-Braddon, M., Taylor, R.M., Fischer, H. & Weidemann, M.J. (1981) Concanavalin A-induced chemiluminescence in rat thymus lymphocytes. Its origin and role in mitogenesis. Biochem. J. 198:661-669
1982
• Hume, D.A. & Gordon, S. (1982) Regulation of bone marrow macrophage proliferation. Adv. Med. Biol. 155: 261-265
1983
• Summers, K.M., Harrison, G.A., Hume, D.A. & Palmer, C.D. (1983) Urinary stress hormone levels: A population study of associations between steroid and catecholamine excretion rates. Annal. Human. Biol. 10:99-110
• Bray, J., Hume, D.A. & Robinson, G.B. (1983) Degradation of rat or sheep glomerular basement membrane by rabbit neutrophils in vitro: the role of proteinases, complement and oxygen-derived radicals. Mol. Biol. Med. 1:253-263
• Hume, D.A. & Gordon, S. (1983) The mononuclear phagocyte system of the mouse defined by immunohistochemical localisation of antigen F4/80. Identification of resident macrophages in renal medullary and cortical interstitium and the juxtaglomerular complex. J. Exp. Med. 157:1704-1709
• Hume, D.A., Perry, V.H. & Gordon, S. (1983) Immunohistochemical localisation of a macrophage-specific antigen in developing mouse retina. Phagocytosis of dying neurons and differentiation of microglial cells to form a regular array in the plexiform layers. J. Cell Biol. 97:253-257
• Hume, D.A., Robinson, A.P., Macpherson, G.G. & Gordon, S. (1983). The mononuclear phagocyte system of the mouse defined by immunohistochemical localisation of antigen F4/80. The relationship between Langerhans cells, reticular cells and dendritic cells in lymphoid and haematopoietic organs. J. Exp. Med. 158: 1522-1536
• Hume, D.A., Gordon, S., Thornalley, P.J. & Bannister, J.V. (1983) The production of oxygen-centred radicals by bacillus-Calmette-Geurin-activated macrophages. An electron paramagnetic resonance study of the response to phorbol myristate acetate. Biochim. Biophys. Acta 763:245-250
• Hume, D.A. & Gordon, S. (1983) Optimal conditions for the proliferation of bone marrow-derived mouse macrophages in culture: The roles of CSF-1, serum, Ca2+ and adherence. J. Cell. Physiol. 117: 189-194
1984
• Hume, D.A. & Gordon, S. (1984) The correlation between plasminogen activator activity and thymidine incorporation in mouse bone marrow-derived macrophages. Opposing effects of colony-stimulating factor, phorbol myristate acetate, dexamethasone and prostaglandin E. Exp. Cell Res. 150: 347-355
• Hume, D.A., Loutit, J.F. & Gordon, S. (1984) The mononuclear phagocyte system of the mouse defined by immunohistochemical localisation of antigen F4/80. Macrophages of bone and associated connective tissue. J. Cell Sci. 66: 189-194
• Hume, D.A., Halpin, D., Charlton, H. & Gordon, S. (1984) The mononuclear phagocyte system of the mouse defined by immunohistochemical localisation of antigen F4/80. Macrophages of endocrine organs. Proc. Nat. Acad. Sci. (USA) 81: 4174-4177
• Hume, D.A., Perry, V.H. & Gordon, S. (1984) The mononuclear phagocyte system of the mouse defined by immunohistochemical localisation of antigen F4/80. Macrophages associated with epithelia. Anat. Rec. 210:503-512
• Hapel, A.J., Warren, H.S. & Hume, D.A. (1984) Different colony-stimulating factors are detected by the interleukin 3-dependent cell lines FDC-P1 and 32D-Cl23. Blood 64:786-790
1985
• Hapel, A.J., Osborne, J.M., Young, I., Fung, M.C., Allan, W. & Hume, D.A. (1985) Expression of 20-a-hydroxysteroid dehydrogenase in mouse macrophages, hemopoietic cells and cell lines and its induction by colony-stimulating factors. J. Immunol. 134: 2492-2497
• Hume, D.A., Allan, W., Golder, J., Stephens, R.W., Doe, W.F. & Warren, H.S. (1985) Preparation and characterisation of human bone marrow-derived macrophages. J. Leuk. Biol.. 38:541-552
• Hume, D.A., Summers, K.M., Cohen, D.R. & Allan, W. (1985) Regulation of the production of granulocyte-macrophage colony-stimulating factor by macrophage-like tumour cells. FEBS Letts. 180: 271-275
• Russell, P.J., Cahill, J., Cameron, F. & Hume, D.A. (1985) Studies of peritoneal macrophage function in mice with systemic lupus erythematosus. II. Nature of elevated peritoneal cells in NZB and (NZB x NZW) F1 mice. J. Leuk. Biol. 38:241-249
• Perry, V.H., Hume, D.A. & Gordon, S. (1985) Immunohistochemical localisation of macrophages and microglia in the developing mouse brain. Neuroscience 173: 313-326
• Stephens, R.W., Golder, J.P., Fayle, D.R.H., Hume, D.A., Hapel, A.J., Allan, W, Fordham, C. & Doe, W.F. (1985) Minactivin expression in human monocyte and macrophage populations. Blood 66: 333-340
• Summers, K.M. & Hume, D.A. (1985) Expression of glandular kallekrein genes in lymphoid and hemopoietic cells and cell lines. Lymphokine Res. 4: 229-234
1986
• Hume, D.A. (1986) Immunohistochemical analysis of mononuclear phagocytes in the mouse that express class II major histocompatibility antigens. Immunobiology 170:381-389
• Dixon, J.E., Allan, J.E., Doherty, P.C. & Hume, D.A. (1986) Immunohistochemical analysis of the role of macrophages in the resolution of lymphocytic choriomeningitis virus infection. J. Leuk. Biol. 40: 617-628
1987
• Mullbacher, A., Hume, D.A., Braithwaite, A.W., Waring, P. & Eichner, R.E. (1987). Selective resistance of bone marrow-derived hemopoietic progenitor cells to gliotoxin. Proc. Natl. Acad. Sci. (USA) 84: 3822-3825
• Hume, D.A., Allan, W., Hapel, A.J., Fabrus, B., Weidemann, M.J. & Bartelmez, S.J. (1987) Regulation of proliferation of bone marrow-derived macrophages. Lymphokine Res. 6: 127-140
• Hume, D.A., Allan, W., Hogan, P.G. & Doe, W.F. (1987) Immunohistochemical characterisation of macrophages in human liver, normal and diseased gastrointestinal tract and associated lymphoid tissue using OKM1, OKIa, OKT4/Leu 3a and the mature macrophage antigen 25F9. J. Leuk. Biol. 42: 474-484
1988
• Russell, P.J., Raghavan, D., Allan, W. & Hume, D.A. (1988) Antigenic variation and macrophage infiltration of human bladder tumors xenografted into nude mice. J. Leuk. Biol. 43: 335-342
• Hume, D.A. (1988) Growth regulation in murine bone marrow-derived macrophages. Effects of contaminating endotoxin in commercial GM-CSF and interleukin 4. Lymphokine Res. 6: 357-359
• Schackert, G., Simmons, R.D., Buzbee, T.M., Hume, D.A. & Fidler, I.J. (1988) Macrophage infiltration into experimental brain metastases occurs through an intact blood-brain barrier. J. Natl. Cancer Inst. 80: 1027-1034
• Hume, D.A., Pavli, P., Donahue, R. & Fidler, I.J. (1988) The effect of human recombinant macrophage colony-stimulating factor on the murine mononuclear phagocyte system in vivo. J. Immunol. 141:3405-3410
• Simeonovic, C.J., Hodder, M.J. & Hume, D.A. (1988) Role of Ia-positive leukocytes and F4/80-positive macrophages in the immunogenicity of fetal mouse proislets and fetal pancreas. Transplant. Proc. 20: 68-71
1989
• Hume, D.A. & Nayar, R. (1989) Encapsulation is not involved in the activities of recombinant gamma interferon associated with multilamellar phospholipid liposomes on murine bone marrow-derived macrophages. Lymphokine Res. 8: 415-427
• Hume, D.A., Donahue, R.E. & Fidler, I.J. (1989) The therapeutic effect of human recombinant macrophage colony stimulating factor (CSF-1) in experimental murine metastatic melanoma. Lymphokine Res. 8: 69-77
• Hume, D.A. & Denkins, Y. (1989) Involvement of a pertussis toxin-sensitive reaction in the activation of macrophages to express cytocidal activity and down-regulation of their responsiveness to macrophage colony-stimulating factor (CSF-1). Immunol. Cell Biol. 67:243-249
1990
• Pavli, P., Doe, W.F. & Hume, D.A. (1990) Isolation and characterisation of antigen-presenting dendritic cells and macrophages from mouse intestinal lamina propria. Immunology. 70: 40-47
• Abd. A.-H.A., Hume D.A., Halliday, W.J. & Davis, G.H.G. (1990) Immunopathological investigations during the course of arthritis induced by Streptococcus agalactiae in Wistar rats. Med. Microbiol. Immunol. 179: 13-23
• Breen, F.N., Hume, D.A. & Weidemann, M.J. (1990) The effects of interleukin 3 (IL3) on cells responsive to macrophage colony-stimulating factor (CSF-1) in liquid bone marrow culture. Br. J. Haematol. 74: 138-147
• Fei Le, Wilce P., Cassady, A.I., Hume, D.A. & Shanley, B. (1990) Acute administration of ethanol suppresses pentylenetetrazole-induced c-fos gene expression. Neuroscience Letts. 120:271-274
1991
• Breen, F.N., Hume, D.A. & Weidemann, M.J. (1991) Interactions between granulocyte-macrophage colony-stimulating factor, macrophage colony-stimulating factor and gamma interferon lead to enhanced proliferation of murine macrophage progenitor cells. J. Immunol. 147:1542-1547
• A.-H.A. Abd, Woolcock, J., Davies, G.H.G., Halliday, W.J. & Hume, D.A. (1991) The role of macrophages in experimental arthritis induced by Streptococcus agalactiae. Actions of macrophage colony-stimulating factor (CSF-1) and other macrophage-modulating agents in vivo. Lymphokine Cytokine Res. 10: 43-50
• Cassady, A.I., Stacey, K.J., Nimmo, K., Murphy, K.M., von der Ahe, D., Pearson, D., Botteri, F.M., Nagamine Y. & Hume , D.A. (1991) Constitutive expression of the urokinase plasminogen activator gene in the murine macrophage cell line RAW.264 involves distal and transcribed 5' non-coding sequences that are conserved between mouse and pig. Nucleic Acids Res. 19:6839-6847.
1992
• Doyle, A., Halliday, W.J., Barnett, C.J., Dunn, T.L. & Hume, D.A. (1992) The effect of recombinant macrophage colony-stimulating factor (CSF-1) on the immunopathology of experimental brucellosis in mice. Infect. Immun. 60: 1465-1473.
• Warren, H.S., Hodder, M.J., Allan, W., Hume, D.A. & Simeonovic, C.J. (1992) Induction of class II major histocompatibility antigens on thyroid, adult pancreatic islet and fetal proislet allografts. Transplantation. 53:834-840.
• Todd, B., Ross, I.L., Hume, D.A. & Pope, J. (1992) The control of HIV production, and HIV enhancer activity in human primary T cells by DEAE Dextran and Interleukin 2. J. Viral Diseases 1:22-33.
• Hume, D.A. & Denkins, Y. (1992) The deleterious effects of macrophage-colony-stimulating factor (CSF-1) on the pathology of experimental candidiasis in mice. Lymphokine Cytokine Res. 11: 95-98
• Le, F., Wilce, P.A., Hume, D.A. & Shanley, B.C. (1992). Involvement of g-aminobutyric acid and N-methyl-D-aspartate receptors in the inhibitory effect of ethanol on pentylenetetrazole-induced c-fos induction in rat brain. J. Neurochem. 59:1309-1315
• Hume, D.A. (1992) The F4/80 antigen is not expressed on eosinophils. J. Leukocyte Biology 51:517-518
1993
• Pavli, P., Hume, D.A., van de Pol, E. & Doe, W.F. (1993). Dendritic cells, the major antigen-presenting cells of the human colonic lamina propria. Immunology. 78:132-141.
• Stacey, K.J., Ross, I.L. & Hume, D.A. (1993) Electroporation and DNA-dependent cell death in murine macrophages Immunol. Cell Biol. 71:75-85.
• Cassady, A.I., King, A., Cross, N. & Hume, D.A. (1993) Isolation and characterization of genes encoding human and murine type-5 acid phosphatase. Gene 130:201-207
• Yue X., von Gavel, S., Cassady, A.I., Stacey, K.J., Dunn, T.L. & Hume, D.A. (1993) The resistance of macrophage-like tumour cell lines to growth inhibition by lipopolysaccharide and pertussis toxin. British J. Haematol. 84:392-401
• Yue, X., Favot, P., Dunn, T.L., Cassady, A.I. & Hume, D.A. (1993). Expression of macrophage colony-stimulating factor receptor (c-fms) mRNA is controlled by a constitutive promoter and tissue-specific transcription elongation. Mol. Cell. Biol. 13:3191-3201
• Murphy, K.M., Sweet, M.J., Ross, I.L. & Hume, D.A. (1993) The nef gene product of HIV-1 causes transcriptional activation of the HIV-1 long terminal repeat and cytostasis in a murine macrophage cell line. Journal of Virology. 67:6956-6964
1994
• Ross, I.L., Browne, C.M. & Hume, D.A. (1994). Transcription of individual genes in eukaryotic cells occurs randomly and infrequently. Immunol. Cell Biol. 72:177-187
• Ross, I.L., Dunn, T.L., Yue, X., Roy, S., Barnett, C.J.K. & Hume, D.A. (1994) The expression and function of the transcription factor PU.1 (Spi-1 proto-oncogene) in macrophages and B lymphocytes. Oncogene 9:121-132
• Reddy, M.A., Yang, B-S, Yue, X., Barnett, C.J.K, Ross, I.L., Sweet, M.J., Hume, D.A. & Ostrowski, M.C. (1994) Opposing actions of c-ets /PU.1 and c-myb protooncogene products in regulating the macrophage-specific promoter of the mouse and human colony-stimulating factor-1 receptor (c-fms) genes. J. Exp. Med. 180: 2309-2319
• Murphy, K.M., Sweet, M.J. & Hume, D.A. (1994) Mechanisms of action of the nef gene product of HIV-1 as a regulator of HIV transcription and cell growth in a murine macrophage cell line. J. Leukocyte Biol. 56: 294-303
• Stacey, K.J., Nagamine, Y. & Hume, D.A. (1994) RNA synthesis inhibition stabilises urokinase mRNA in macrophages. FEBS Letts.356:311-313
1995
• Hume, D.A. & Favot P.S. (1995). Is the osteopetrotic (op/op mutant) mouse completely deficient in expression of macrophage colony-stimulating factor (CSF-1). J. Interferon Cytokine Res. 15. 279-284
• Stacey, K.J., Fowles, L.F., Sweet, M.S., Colman, M.S., Ostrowski, M.J. & Hume, D.A. (1995). Regulation of the expression of the urokinase plasminogen activator gene in macrophages by macrophage colony-stimulating factor (CSF-1) and phorbol esters. Mol. Cell Biol. 15:3430-3441
• Chen, C., Clarkson, R.W.E., Yue, X., Hume, D.A. & Waters, M.J. (1995) Growth hormone and CSF-1 share multiple response elements in the c-fos promoter. Endocrinol. 136:4505-4516
• Sweet, M.J. & Hume, D.A. (1995) RAW264 macrophages transfected with an HIV-1-long terminal repeat reporter gene provide a sensitive bioassay for analysis of signalling pathways in macrophages stimulated or taxol. J.with lipopolysaccharide, tumor necrosis factor- Inflammation. 45:126-135
• Hume, D.A., Monkley, S.J. & Wainwright, B.J. (1995) Detection of the c-fms protooncogene in early mouse embryos by whole mount in situ hybridisation indicates roles for macrophages in tissue remodelling. British. J. Haematol. 90:939-942
• Favot, P.F., Yue, X. & Hume, D.A. (1995) Regulation of the c-fms promoter in murine tumour cell lines. Oncogene 11:1371-1381
• Sweet, M.J. & Hume, D.A. (1995). Bacterial lipopolysaccharide confers resistance to G418, doxorubicin and taxol in the murine macrophage cell line, RAW264. J. Leukocyte Biology. 59:280-286
1996
• Delaney, S.J., Alton, E.W.F.W., Dorin, J.R., Smith, S.J., Lunn, D.P., Farini, E., Farley, R., Hume, D.A., Lamb, D., Porteous, D.J. & Wainwright, B.J. (1996) Cystic fibrosis mice carrying the missense mutation G551D replicate human genotype-phenotype correlations. EMBO J. 15:955-964.
• Yang, B-S., Hauser, C.A., Ghenkel, G., Colman, M.S., van Beveren, C., Stacey, K.J., Hume, D.A., Maki, R.A., Ostrowski, M.C. (1996) Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets-1 and c-Ets2. Mol. Cell. Biol. 16:538-547.
• Symons, A.L., McKay, C.A., Leong, K., Hume, D.A., Waters, M.J. & Marks, S.C. Jr. (1996) Decreased growth hormone receptor expression in long bones from Toothless (osteopetrotic) rats and restoration by treatment with colony-stimulating factor-1. Growth Factors. 13: 1-10
• Yue, X, Ross, I.L., Browne, C.M., Lichanska, A., Favot, P., Ostrowski, M.C. & Hume, D.A. (1996) Transcriptional control of the expression of the c-fms gene encoding the receptor for macrophage colony-stimulating factor. Immunobiology. 195:461-476
• Stacey, K.J., Sweet, M.J. & Hume, D.A. (1996) Macrophages ingest and are activated by bacterial DNA. J. Immunol. 157:2116-2122
• Dunn, T.L., Ross I.L. & Hume, D.A. (1996) Transcription factor Oct-2 is expressed in primary murine macrophages. Blood. 88:4072-4073
1997
• Jessup, W., Squires, B., Kritharides, L., Hume, D.A., Dean, R.T. (1997). The role of CSF-1 in cholesterol homeostasis. Atherosclerosis, Thrombosis and Vascular Biology 17:18-25
• D'Orazio, D., Besser, D., Marksitzer, R., Kunz, C., Hume, D.A., Kiefer, B. & Nagamine, Y. (1997) Cooperation of two PEA3/AP1 sites in uPA gene induction by TPA and FGF-2. Gene 201:179-187.
• Marshall, K., Nash, K., Haussman, G., Cassady, A.I., Hume, D.A., de Jersey, J., Hamilton, S. (1997). Recombinant human and mouse purple acid phosphatases: Expression and characterisation. Arch. Biochem. Biophys. 345:230-236
1998
• Ross, I.L., Yue, X., Ostrowski, M.C., Hume, D.A. (1998) Interaction between PU.1 and another Ets family transcription factor promotes macrophage-specific basal transcription initiation. J. Biol. Chem. 273:6662-6669
• Sweet, M.J., Stacey, K.J., Kakuda, D.K., Markovitch, D. & Hume, D.A. (1998) IFN-gamma primes macrophage responses to bacterial DNA. J. Interferon. Cytokine Res. 18:263-272
• Sweet, M.J., Stacey, K.J. , Ross, I.L., Ostrowski, M.C. & Hume, D.A. (1998) The involvement of Ets, rel and Sp1-like proteins in the lipopolysaccharide-mediated activation of the HIV-1-LTR in macrophages. J. Inflammation . 48:67-83.
• Osborne, J.M., den Elzen, N., Lichanska, A.M., Costelloe, E.O., Yamada, Y., Cassady, A.I., Hume, D.A. (1998). Murine DEP-1, a receptor protein tyrosine phosphatase, is expressed in macrophages and is regulated by CSF-1 and LPS J. Leukocyte Biol. 64:692-701
• Fowles, L.F., Martin, M.L., Nelsen, L., Stacey, K.J., Redd, D., Clark, Y.M..,Nagamine, Y., McMahon, M., & Hume, D.A. & Ostrowski, M.C. (1998) Persistent activation of MAP kinases p42/44 and Ets-2 phosphorylation in response to CSF-1/c-fms signalling. Mol. Cell Biol. 18:5148-5156
1999
• Chang, S., Stacey, K.J., Costelloe, E.O., Aderem, A. & Hume, D.A. (1999) Mechanisms of regulation of the MacMarcks gene in macrophages. J. Leukocyte Biol. 66:528-534
• Costelloe, E.O., Stacey, K.J., Antalis, T.M., Hume, D.A. (1999). Regulation of the plasminogen activator inhibitor type 2 gene in murine macrophages. Demonstration of a novel pattern of responsiveness to bacterial endotoxin. J. Leukocyte Biol. 66:172-183
• Rehli, M., den Elzen, N., Cassady, A.I., Ostrowski, M.C. & Hume, D.A. (1999). Cloning and characterisation of the murine genes for bHLH-ZIP factors TFEC and TFEB reveals a common gene organisation for all MiT-subfamily members. Genomics. 56:111-120.
• Lichanska, A.M., Browne, C.M., Henkel, G.W., Murphy, K.M., Ostrowski, M.C., McKercher, S.R., Maki, R.A. & Hume, D.A. (1999) Differentiation of the embryonic mononuclear phagocyte system. The role of transcription factor PU.1. Blood 94:127-138
• Rehli, M. , Lichanska, A., den Elzen, N., Ostrowski, M.C. & Hume, D.A. (1999) TFEC is a macrophage-restricted member of the MiT-subfamily of bHLH-ZIP transcription factors. J. Immunol. 162:1559-1565
• Joseph, B.K., Marks, S.C. Jnr, Hume, D.A., Waters, M.J., Symons, A.L. (1999). Insulin-like growth factor-1 (IGF-1) and IGF-1 (IGF-1R) expression in normal and osteopetrotic (toothless, tl,tl) rat bone. Growth Factors 16:279-291
• Kakuda, D.K., Sweet, M.J., McCleod, C.L., Hume, D.A. & Markovitch, D. (1999) CAT2-mediated L-arginine transport and nitric oxide production in activated macrophages. Biochem J. 340:549-553
• Guddat, L.W., McAlpine, A., Hume, D.A., Hamilton, S., de Jersey, J., Martin, J.L. (1999). Crystal structure of mammalian purple acid phosphatase. Structure 7:757-767
• Passey, R.J., Williams, E., Wells, C., Lichanska, A.M., Geczy, C.L., Little, M.H. & Hume, D.A. (1999) A null mutation in the inflammation-associated S100 protein, S100A8, causes early resorption of the mouse embryo. Journal of Immunology 163:2209-2216
• Guddat, L.W., McAlpine, A.S., Hume, D.A., de Jersey, J., Hamilton, S., Martin, J.L. (1999) Crystallization and preliminary X-ray diffraction studies of mammalian purple acid phosphatase Acta Crystallographica. D52:1462-1464
• Sester, D.P., Beasley, S., Sweet, M.J., Fowles, L.F., Cronau, S.J., Stacey, K.J. & Hume, D.A. (1999) Immunostimulatory DNA down-modulates CSF-1 receptor surface expression on murine macrophages with concomitant growth arrest and factor-independent survival. Journal of Immunology. 163:6541-6550
2000
• Angel, N.Z., Cahill, M., King, A.,& Ostrowski, M.C., Cassady, A.I. & Hume. D.A. (2000). Transgenic mice that overexpress the tartrate-resistant acid phosphatase gene exhibit an increased rate of bone turrnover. J. Bone & Mineral Research. 15:103-110.
• Luchin, A., Purdom, G., Murphy, K., Clark, M-Y., Angel, N.Z., Cassady, A.I., Hume, D.A. & Ostrowski, M.C. (2000) The microphthalmia transcription factor regulates expression of the tartrate resistant acid phosphatase gene during terminal differentiation of osteoclasts. Journal of Bone and Mineral Research. 15:451-460.
• Dwidedi, P.P., Omdahl, J.L., Kola, I., Hume, D.A. & Kay, B.K. (2000). Regulation of rat 25-hyrdoxyvitamin D3 24-hydroxylase (CYP24) gene expression: Evidence for cooperation of ras-activated Ets transcription factors with vitamin D receptor in 1,25-(OH)2D3-mediated induction. Journal of Biological Chemistry. 275:47-55.
• Thomas, G., McMorran, B., Ahadizadeh, A., McGlinn, E., Lunn, D., Lovelock, P., Delaney, S., Costelloe, E.O., Stacey, K.J., Passey, R., Geczy, C. , Wainwright, B. & Hume, D.A. (2000) The cystic fibrosis transmembrane conductance regulator (CFTR) regulates the sensitivity of macrophages to bacterial lipopolysaccharide. Journal of Immunology 164:3870-3877
• Fowles, L.F. Stacey, K.J., Marks, D. Hamilton, J.A. & Hume, D.A. (2000). Regulation of the urokinase plasminogen activator gene in macrophages by macrophage colony-stimulating factor (CSF-1) is dependent upon the level of cell surface receptor. Biochem. J. 347:313-320
• Schenk, G., Ge, Y., Guddat, L.W., Carrington, L.E., Hume, D.A., Hamilton, S.E. & de Jersey, J. (2000) Identification of mammalian-like purple acid phosphatases in a wide range of plants. Gene 250:117-125
• Smith, J.A., Schaffner, A.E., Wei, G., Forsthoefel, D., Pranad, A., Coggeshall, K.M., Hume, D.A. and Ostrowski, M.C. (2000) Ets-2 is a target for a CSF-1-independent Akt signalling pathway in macrophages of motheaten-viable mice. Mol. Cell. Biol. 20:8026-8034
• Shurety, W., Merino-Trigo, A., Brown, D., Chambers, D.A., Hume, D.A. & in macrophagesStow, J.L. (2000). Post Golgi trafficking of TNF- . J. Interferon.Cytokine Res. 20:427-438is controlled by interferon-
• Sester, D.P., Naik, S., Beasley, S., Hume, D.A. & Stacey, K.J. (2000). Phosphorothioate backbone modification modulates activation of murine macrophages by CpG DNA. J. Immunol. 165:4165-4173.
• Schenk, G., Korsinczky, M.L.J., Hume, D.A. Hamilton, S.E., de Jersey, J. (2000) Purple acid phosphatases from bacteria: similarities to mammalian and plant enzymes. Gene 255:419-424.
• Goldring, C.E.P., Reveneau, S., Chantome, A., Pance, A, Fleury, C., Hume, D.A., Sester, D.P., Mignotte, B., Jeannin, J-F. (2000). Heat shock enhances transcriptional activation of the murine inducible nitric oxide synthase gene. FASEB J. 15:2393-2395
• Hume, D.A. (2000) Probability in transcriptional regulation and its implications for leukocyte differentiation and inducible gene expression. Blood 96:2323-2328.
2001
• Ozinsky, A., Smith, K.D., Hume, D.A., Underhill, D.M. (2001) Cooperation between TLR2 and TLR6 during signaling. J. Endotoxin Res. 6:393-396
• Riken Genome Exploration Phase II Group and FANTOM Consortium (2001) (Hume, D.A. acknowledged as major contributor and project organiser amongst 90 authors). Functional annotation of a collection of mouse full length cDNAs. Nature. 409:685-690
• Himes, R., Tagoh, H., Goonetilleke, N., Sasmono, R.T., Oceandy, D., Clark, R., Bonifer, C. Hume, D.A. (2001). A highly conserved intronic element in the c-fms (CSF-1 receptor) gene controls macrophage-specific and regulated expression. J. Leukocyte Biology 70:812-820.
• Wardrop, S.L., Wells, C.A., Ravasi, T., Richardson, D., Hume, D.A. (2001). Both IRE and non-IRE isoforms of the mouse nRAMP2 gene are induced in activated macrophages regardless of nRAMP1 genotype. Dissociation from induction of inflammatory cytokines and gene involved in iron metabolism using cDNA microarrays. J. Leukocyte Biology. 71:99-106
• Hume, D.A., Underhill, D.M., Sweet, M.J., Ozinsky, A., Fontenot, J.D., Liew, F.Y., Aderem, A. (2001). Macrophages exposed to lipopolysaccharide and other agonists that act via Toll-like receptors exhibit a sustained and additive activation state. BioMed Central-Immunology 2:11
• Luchin, A., Suchting, S., Merson, T., Rosol, T.J., Hume, D.A., Cassady, A.I. & Ostrowski, M.C. (2001). Genetic and physical interactions between microphthalmia transcription factor and PU.1 are necessary for osteoclast gene expression and differentiation. J. Biol. Chem. 276:36703-36710.
2002
• Ravasi, T., Wells, C.A., Forrest, A.,Walsh, N., Underhill, D.M., Wainwright, B.J., Aderem, A., Grimmond, S., Hume, D.A. (2002). Generation of diversity in the innate immune system. Macrophage heterogeneity arises from gene-autonomous transcription probability of individual inducible genes. J. Immunol. 168:44-50
• Sweet, M.J., Campbell, C.C., Sester, D.P., Xu, D., Stacey, K.J., Hume, D.A., Liew, F.Y. (2002). CSF-1 suppresses response to CpG DNA and expression of toll-like receptor 9, but enhances responses to lipopolysaccharide in murine macrophages. J. Immunol. 168:392-399.
• Mansky, K.C., Marfatia, K., Luchin, A., Purdom, G.H., Hume, D.A., Ostrowski, M.C. (2002). Regulation of gene expression by the microphthalmia transcription factor (MITF): characterization of a distinct N-terminal activation domain required for target gene activation and differentiation in osteoclasts. J. Leukocyte Biology. 71:295-303
• Oceandy, D., McMorran, B.J., Smith, S.N., Alton, E.W.F.W., Hume, D.A., Wainwright, B.J. (2002) Gene complementation of airway epithelium in the cystic fibrosis mouse is necessary and sufficient to correct the pathogen clearance and inflammatory abnormalities. Human Molecular Genetics. 11:1059-1067
• McMorran, B.J., Palmer, J., Lunn, D.P., Oceandy, D., Costelloe, E., Thomas, G.R., Hume, D.A., Wainwright, B.J. (2002) G551D cystic fibrosis mice display an abnormal host response and have impaired clearance of pseudomonas lung infection. Am. J. Physiol. 281:L740-L747
• Mansky, K.C., Sultzbacher, S., Purdom, G., Nelsen, L., Hume, D.A. Rehli, M. & Ostrowski, M.C. (2002) The microphthalmia transcription factor and the related helix-loop-helix factors TFE-3 and TFE-C collaborate to activate TRAP gene expression in murine osteoclasts. J. Leukocyte Biology 71:304-310
• Yue, X., Chen, C., Stevenson, M.A., Hume, D.A., Auron, P.E. & Calderwood, S.K. (2002). NF-IL6 and HSF1 have mutually-antagonists effects on transcription in monocytic cells. Biochem. Biophys. Res. Commun.291:1071-1080.
• Tagoh, H., Himes, S.R., Clarke, D., Leenen, P., Riggs, A.D., Hume, D.A. & Bonifer, C. (2002) Dynamics of transcription factor complex formation and chromatin fine structure alterations at the murine c-fms (CSF-1 receptor) locus during the differentiation of purified myeloid precursor cells into activated macrophages. Genes.Dev. 16:1721-173
• Okazaki, Y. The FANTOM Consortium and the RIKEN Genome Exploration Research groups Phase 1 and 2 Team (Hume, D.A. cited a member of the core authorship and planning team). (2002). Analysis of the mouse transcriptome based upon functional annotation of 60,770 full length cDNAs. Nature, 420:563-573
2003
• Stacey, K.J., Young, G.R., Clark, F., Sester, D.P., Roberts, T.L., Naik, S., Sweet, M.J., Hume, D.A. (2003) The molecular basis for the lack of immunostimulatory activity of vertebrate DNA. J.Immunol. 170:3614-3620
• Walsh, N.C., Cahill, M., Carninci, P., Kawai, J., Okazaki, Y., Hayashizaki, Y., Hume, D.A., Cassady, A.I. (2003). Multiple tissue-specific promoters control expression of the murine tartrate-resistant acid phosphatase gene. Gene. 307:111-123
• Zavolan, M., Kondo, S., Schonbach, C., Adachi, J., Hume, D.A., Hayashizaki, Y. & Gaasterland, T. (2003). Impact of alternative initiation, splicing and termination on the diversity of mRNA transcripts encoded by the mouse transcriptome. Genome Res. 1290-1300.
• Sasmono, R.T., Oceandy, D., Pollard, J., Tong, W., Himes, S.R., Hume, D.A. (2003). Definition of the mononuclear phagocyte system of the mouse using a macrophage colony-stimulating factor receptor (CSF-1R)-green fluorescent protein transgene. Blood. 101:1155-1163
• Forrest, A.R.R., Ravasi, T., Hume, D.A., Taylor, D., Huber, T. & Grimmond, S. (2003) Phosphoregulators: Protein kinases and Protein phosphatases. Genome Res. 13:1443-1454
• Numata, K., Kanai, A., Saito, R., Kondo, S., Adachi, J., Wilming, L.G., Hume, D.A., Hayashizaki, Y., Tomita, M. (2003) Identification of putative non-coding RNAs in the RIKEN mouse full length cDNA collection. Genome Res. 13:1301-1306
• Wells, C.A., Ravasi, T., Sultana, R., Yagi, K., Carninci, P., Bono, H., Okazaki, Y., Quackenbush, J., Hume, D.A., Lyons, P. (2003) Continued discovery of transcriptional units expressed in cells of the mouse mononuclear phagocyte lineage. Genome Res. 13:1360-1365
• Ravasi, T., Huber, T., Zavolan, M., Forrest, A., Gaasterland, T., Grimmond, S. & Hume, D.A. , (2003). Systematic characterisation of zinc finger-containing proteins in the mouse transcriptome. Genome Res. 13:1430-1442
• Grimmond, S., Miranda, K., Yuan, Z., Davis, M.J., Hume, D.A., Yagi, K., Tominaga, N., Bono, H., Hayashizaki, Y., Okazaki, Y. & Teasdale, R.D. (2003) The mouse secretome. Functional classification of the proteins secreted into the extracellular environment. Genome Res. 13:1350-1359
• Kasukawa, T., Furuno, M., Nikaido, I., Bono, H., Okazaki, Y., Hume, D.A., Bult, C., Hill, D.P., Baldarelli, R., Gough, J., Karapin, A., Matsuda, H., Schriml, L., Hayashizaki, Y., Okazaki, Y. & Quackenbush, J. (2003) Development and evaluation of the automated annotation pipeline and cDNA annotation system Genome Res. 13:1542-1551
• Tajul-Arifin, K., Teasdale, R., Ravasi, T., Hume, D.A., Mattick, J.S. (2003). Identification and analysis of chromodomain-containing proteins encoded in the mouse transcriptome. Genome Res. 13:1416-1429
• Bono,H., Yagi, K., Kasukawa, T., Nikaido, I., Tominaga N., Miki, R., Mizuno, Y., Tomaru, Y., Goto,H., Nitanda, H., Shimizu, D., Makino, H., Morita, T., Fujiyama, J., Sakai, T., Shimoji, T., Hume, D.A., Hayashizaki, Y., and Okazaki Y. (2003) Systematic expression profiling of the mouse transcriptome using RIKEN cDNA microarrays. Genome Res. 13:1318-1323
• Carninci, P. et al. (46 authors, including Hume, D.A.). (2003) Targeting a complete transcriptome. The construction of the mouse full length cDNA encyclopaedia. Genome Res. 13:1273-1289
• McMorran, B., Town, L., Costelloe, E., Palmer, J., Engel, J., Hume, D.A., Wainwright, B. (2003). The type III-secreted effector ExoU is an important modulator of gene expression in lung epithelial cells in response to pseudomonas aeruginosa in infection. Infection & Immunity 71:6035-6044
• Wells, C.A., Ravasi, T., Faulkner, G.J., Carninci, P., Okazaki, Y., Hayashizaki, Y., Sweet, M.J., Wainwright, B.J., Hume, D.A. (2003) Genetic control of the innate immune response. BioMed Central-Immunology. 4:5 (26 June).
• Cassady, A.I., Luchin, A., Ostrowski, M.C. & Hume, D.A. (2003). Regulation of the murine TRACP gene promoter. J. Bone Mineral Res. 18:1901-1904.
2004
• Ravasi, T., Hsu, K., Goyette, J., Schroder, K., Yang, Z., Miranda, L.P, Alewood, P.F., Hume, D.A. & Geczy, C. (2004) Probing the S100 protein family through genomic and functional analysis. Genomics. 84:10-22.
• Valizadeh, M., Schenk, G., Nash, K., Oddie, G.W., Guddat, L.W., Hume, D.A., de Jersey, J., Burke, T.R., Hamilton, S. (2004) Phosphopeptide peptides and analogues as substrates and inhibitors of purple acid phosphatases. Arch. Biochem. Biophys. 424:154-162
• Tagoh, H., Schebesta, A., LeFevre, P., Wilson, N., Hume, D.A., Busslinger, M. & Bonifer, M. (2004). Epigenetic silencing of the c-fms locus during B lymphopoiesis occurs in discrete steps and is reversible. EMBO J. 23:4275-4285
• Kasukawa, T, Katayama, S., Kawaji, H., Suzuki, H., Hume, D.A., Hayashizaki, Y. (2004) Construction of representative transcript and protein sets (RTPS) of human, mouse and rat. A platform for their transcriptome and proteome analysis. Genomics. 84:913-921
2005
• Bozinovski, S., Cross, M., Vlahos, R., Jones, J.E., Xu, K., Tessier, P.A., Hume, D.A., Hamilton, J.A., Geczy, C., Anderson, G.P. (2005). S100A8 chemotactic protein is abundantly increased, but only a minor contributor to LPS-induced, steroid resistant neutrophilic lung inflammation in vivo. Journal of Proteome Research. 4:136-145
• Mitic, N., Valizadeh, M., Leung, E.W., de Jersey, J., Hamilton, S., Hume, D.A., Cassady, A.I. & Schenk, G. (2005) Human tartrate-resistant acid phosphatase becomes an effective ATPase upon proteolytic activation. Arch. Biochem. Biophys. 439:154-164
• Aagaard, A., Listwan, P., Cowieson, N., Huber, T., Ravasi, T., Wells, C., Flanagan, J.U., Hume, D.A., Kobe, B., Martin, J.L. (2005). An anti-inflammatory role for the mammalian carboxypeptidase inhibitor latexin. Relationship to cysteine protease inhibitors and the tumor suppressor TIG1. Structure. 13:309-317
• Rehli, M., Sulzbacher, S., Pape, S., Ravasi, T., Wells, C.A., Heinz, S., Sollner, L., el Chartouni, C., Krause, S.W., Steingrimmson, E., Hume, D.A., Andreesen, R. (2005) Transcription factor tfec is induced by interleukin 4 and contributes to the inducible expression of a small group of genes including the granulocyte stimulating factor receptor in macrophages. J. Immunol. 174:7111-7122
• Roberts, T.L., Sweet, M.J., Hume, D.A., Stacey, K.J. (2005) Cutting Edge: Species-specific TLR9-mediated recognition of CpG and non CpG phosphorothioate-modified oligonucleotides. J.Immunol. 174:605-608
• Himes, S. R., Cronau, S., Mulford, C. & Hume, D.A. (2005). The runx1 transcription factor controls CSF-1 dependent and independent growth and survival of macrophages. Oncogene. 24:5278-5286
• Cowieson, N., Listwan, P., Kurz, M., Aagaard, A., Ravasi, T., Wells, C., Huber, T., Hume, D.A., Kobe, B., Martin, J.L. (2005). Pilot studies on the parallel production of soluble mouse proteins in a bacterial expression system. J.Structural. Functional Genomics. 6:13-20
• MacDonald, K.P.A., Rowe, V., Thomas, R., Hume, D.A. & Hill, G.R. (2005) The CSF-1 receptor is expressed on dendritic cells during differentiation and regulates their expansion. J. Immunol. 175:1399-1405
• Murphy, R.Z., Wylie, F.G., Kromyck, T., Hume, D.A. & Stow, J.L. (2005). Syntaxin 6 and vti1b form a novel SNARE complex which is upregulated in activated macrophages to facilitate exocytosis of TNFa. J. Biol. Chem. 280:10478-10483
• Raisanen, S.R., Alatalo, S.L., Ylipahkala, H., Halleen, J.M., Cassady, A.I., Hume, D.A., Vaananen, H.K. (2005) Macrophages overexpressing tartrate-resistant acid phosphatase show altered profile of free radical production and enhanced capacity for bacterial killing, Biochem. Biophys. Res. Commun. 331:120-126
• Katayama, S., Tomaru, Y., Kasukawa, T., Waki, K., Suzuki, M., Nishida, H., Choo, Y-C, Kawai, J., Suzuki, H., Carninci, P., Hayashizaki, Y., Wells, C., Frith, M., Ravasi, T., Pang, K., Mattick, J., Hume, D.A. Lipovich, L., Engström, P.G., Mizuno, Y., Faghihi, M.A., Sandelin, A., Chalk, A., Mottagui-Tabar, S.. Lenhard, B., & Wahlestedt, C. (2005). Antisense transcription in the mammalian transcriptome. (Author listing based upon group affiliations, DAH senior author). Science. 309:1564-1566
• P.Carninci et al. The FANTOM Consortium, RIKEN Genome Science Laboratory and RIKEN Genome Exploration Research Group (2005) (Hume, D.A. named as member of authorship group and last author of the FANTOM Consortium). The Transcriptional Landscape of the Mammalian Genome. Science. 309:1559-1563
• Roberts, T., Sweet, M.J., Hume, D.A. & Stacey, K.J. (2005) Differences in macrophage activation between bacterial DNA and CpG-containing oligonucleotides. J.Immunol. 175:3569-3576
• Cochrane, A.L., Kett, M.M., Samuel, C.S., Campanale, N.V., Anderson, W.P., Hume, D.A., Little, M.H., Bertram, J.F. & Ricardo, S.D. (2005) Renal structural and functional repair in a mouse model of reversal of ureteral obstruction. J. Amer. Soc. Nephrol. 16:3623-3630.
• Ripoll, V.M., Hume, D.A. & Fontanilla, M.R. (2005) Expresion especifica de los genes de la respuesta inflamatoria en subpoblaciones de macrofagos. Biomedica 25:261-270. (in Spanish, abstract in English)
• Sester, D.P., Trieu, A., Brion, K., Schroder, K., Ravasi, T., Robinson, J.A., McDonald, R.C., Ripoll, V., Wells, C.A., Suzuki, H., Stacey, K.J., Hume, D.A., Sweet, M.J. (2005) LPS regulates a set of genes in primary murine macrophages by antagonizing CSF-1 action. Immunobiol. 210:97-107
• Listwan, P., Cowieson, N., Kurtz, M., Hume, D.A., Martin, J.L. & Kobe, B. (2005) Modification of recombinatorial cloning for small affinity tag fusion protein construct generation. Anal. Biochem. 346:327-329
• Mouradov, D., Craven, A., Forwood, J.K., Flanagan, J.U., Garcia-Castellanos, R., Gomis-Ruth, F.X., Hume, D.A., Martin, J.L., Kobe, B. & Huber, T. (2005) Modelling the structure of latexin-carboxypeptidase A complex based on chemical cross-linking and molecular docking. Protein Engineering, Design and Selection. 19:9-16 (Epub Oct 25)
2006
• Ravasi, T., Suzuki, H., Pang, K., Katayama, S., Furono, M., Okunishi, R., Fukuda, S., Hume, D.A., Hayashizaki, Y. & Mattick, J.S. (2005). Experimental validation of the regulated expression of large numbers of non-coding RNAs from the mouse genome. Genome Res. 16:11-19
• Serek, R., Forwood, J.K., Hume, D.A., Martin, J.L. & Kobe, B. (2006) Crystallisation of the C-terminal domain of the mouse brain long chain acyl-CoA thioesterase. Acta Crystallographica F. 62:133-5
• Carninci, P. Sandelin, T.A., Lenhard, B., Katayama, S., Shimokawa, K., Ponjavic, J., Semple C.A.M., Taylor, M.S., Engstrom, P., Frith, M.C., Forrest, A.R., Alkema, W.B., Tan, S.L., Plessy, C., Kodzius, R., Ravasi, T., Kasukawa, T., Fukuda, S., Kanamori-Katayama, M., Kitazume, Y., Kawaji, H., Kai, C., Nakamura, M., Konno, H., nakano, K., Mottagui-Tabar, S., Arner, P., Chesi, A., Gustincich, S., Persichetti, F., Suzuki, H., Grimmond, S.M., Wells, C.A., Orlando, V., Wahlstedt, C., Liu, E.T., Harbers, M., Kawai, J., Bajic, V.B., Hume, D.A. & Hayashizaki, Y. (2006) Genome-wide analysis of mammalian promoter architecture and evolution. Nature Genetics. 38:626-635 DAH equal first author and joint corresponding author. Commentary in Nature, Nature Reviews in Genetics and Nature Methods.
• Hume, D.A. (2006). Comment on "CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes". J.Immunol. 17:2035
• Nilsson, R., Bajic, V., Katayama, S., Suzuki, H., Reif, J.F., Tan, S-L., Sweet, M.J., Bersano-Begey, T.F., Gariboldi, M., Nori, F., Kai, C., Kawai, J., Carninci, P., Hayashizaki, Y., Hume, D.A., Tegner, J. & Ravasi, T. (2006) Transcriptional network dynamics in macrophage activation. Genomics 88:133-142
• Wells, C.A., Chalk, A., Forrest, A., Taylor, D., Waddell, N., Schroder, K., Himes, S.R., Faulkner, G., Lo, S., Kasukawa, T., Kawaji, H., Kai, C., Kawai, J., Katayama, S., Carninci, P., Hayashizaki, Y., Hume, D.A., Grimmond, S.M. (2006) Alternative transcription of the toll-like receptor signalling cascade. Genome Biology. 7:R10
• Aung, H.T., Schroder, K., Himes, S.R., Brion, K., van Zuylen, W., Trieu, A., Suzuki, H., Hayashizaki, Y., Hume, D.A., Sweet, M.J. & Ravasi, T. (2006) LPS regulates pro-inflammatory gene expression in macrophages by altering histone deacetylase expression. FASEB J. 20:1315-27
• Maeda, N., Kasukawa, T., Oyama, R., Gough, J., Frith, M., Aturaliya, R.N., Batalov, S., Beisel, K.W., Bult, C., Fletcher, C.F., Forrest, A., Furuno, M., Hill, D., Itoh, M., Kanamore-Katayama, M., Katayama, S., Katoh, M., Kawashima, T., Quackenbush, J., Ravasi, T., Ring, B.Z., Shibata, K., Suguira, K., Takenaka, Y., Teasdale, R.D., Well, C.A., Zhu, Y., Kai, C., Kawai, J., Hume, D.A., Carninci, P., Hayashizaki, Y. (2006) Transcript annotation in FANTOM 3-A mouse gene catalogue based on physical cDNAs. PLoS Genetics. 2:e62 (Epub Apr 28)
• Flanagan, J.U., Cassady, A.I., Schenk, G., Guddat, L.W., Hume, D.A. (2006) Identification and molecular modelling of a novel, plant-like, human purple acid phosphatase. Gene 377:12-20
• Schroder, K., Sweet, M.J. & Hume, D.A. (2006) Signal integration between IFNg and TLR signaling pathways in macrophages. Immunobiology. 211:511-524
• Bajic, V.B., Tan, S.L., Christoffels, A., Schonbach, C., Lipovich, L., Yang, L., Hofmann, O., Kruger, A.. Hide, W., Kai, C., Kawai, J., Hume, D.A., Carninci, P., Hayashizaki, Y. (2006) Of mice and men: Their promoter properties. Plos Genetics. 2:e54 (EpubApr28)
• Yan, C., Lian, X., Dai, Y., White, A., Qin, Y., Hume, D.A. & Du, H. (2006) Macrophage-specific expression of human lysosomal acid lipase corrects inflammation and pathogenic phenotypes in lal-/- mice. Am. J. Pathol. 169:916-926
• Inoue, K., Kobayashi, M., Izumi, A., Doi, T.,, Mataki, C., Hume, D.A. Aird, W.C., Kodama, T., Minami, T. (2006) Histone deacetylase inhibitor reduces monocyte adhesion to endothelium through the suppression of VCAM-1 expression. Arteriosclerosis, Thrombosis and Vascular Biology. 26:2652-2659
• Irvine, K.M, Burns, C.J., Wilks, A.F., Su, S., Hume, D.A., Sweet, M.J. (2006) CSF-1 receptor kinase inhibitors target effector functions and inhibit pro-inflammatory cytokine production from murine macrophage populations. FASEB J 20:1921-30.
• Wu, ACK, Grondahl, L., jack, K.S., Foo, M.X., Trau, M., Hume, D.A. Cassady, A.I., (2006) Reduction of the in vitro pro-inflammatory response by macrophages to poly(3-hydroxybutyrate-co-3hydroxyvalerate) BioMaterials 27:4715-4725
• Himes, S.R., Sester, D.P, Cronau, S., Sasmono, T., Mulford, C. , Hume, D.A. (2006) The c-jun N-terminal kinases are important for the development and survival of macrophages. J.Immunol. 176:2219-2228
• Sester, D.P., Brion, K., Trieu, A., Goodridge, H.S., Roberts, T.L., Dunn, J., Hume, D.A., Stacey, K.J., Sweet, M.J. (2006) CpG DNA activates survival in murine macrophages through tlr9 and the phosphatidyl inositol 3-kinase-akt pathway. J.Immunol. 177:4473-4480
• Kurz, M., Cowieson, N.P., Robin, G., Hume, D.A., Alber, T., Kobe, B., Martin, J.L. & Listwan, P. (2006) Incorporating a TEV cleavage site reduces the solubility of nine tested recombinant mouse proteins. Protein Expr. Purif. 6:1750-1757
• Cowieson, N.P., Wensley, E., Listwan, P., Hume, D.A., Kobe, B., Martin, J.L. (2006) An automatable screen for the rapid identification of proteins amenable to refolding. Proteomics 6:1750-7
• Brahmachary, M., Schoenbach, C., Yang, L., Huang, E., Tan, S.L., Chowdhary, R., Krishnan, S.P.T., Lin, C.Y., Hume, D.A., Kai, C., Kawai, J., Carninci, P., Hayashizaki, Y., Bajic, V.B. (2006). Computational promoter analysis of mouse, rat and human antimicrobial peptide-coding genes. BMC Bioinformatics. 7/S8
2007
• Meadows, N.A., Sharma, S.M., Faulkner, G.J., Ostrowski, M.C., Hume, D.A., Cassady, A.I. (2007). The expression of chloride channel 7 (CLCN7) and OstM1 in osteoclasts is co-regulated by microphthalmia transcription factor. J.Biol. Chem. 282:1891-1904
• Bode, K.A., Schroder, K., Hume, D.A., Ravasi, T., Heeg, K., Sweet, M.J. & Dalpke, A.H. (2007) Histone deacetylase inhibitors decrease toll-like receptor-mediated cytokine production. Immunology 122:596-606
• Sasmono, R.T., Ehrnsperger, A., Cronau, S.L., Ravasi, T., Kandane, R., Hickey, M.J., Cook, A.D., Himes, S.R., Hamilton, J.A. & Hume, D.A. (2007) Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts, and can transdifferentiate into macrophages in vitro in response to CSF-1. J.Leukocyte Biol. 82:111-123
• Zreiqat, H., Howlett, C.R., Gronthos, S., Hume, D. & Geczy, C.L. (2007) S100A8/S100A9 and their association with cartilage and bone. J. Mol. Histol. 38:381-391
• Schroder K, Spille M, Pilz A, Lattin J, Bode K.A., Irvine K.M., Burrows A.D., Ravasi T, Weighardt H, Stacey K.J., Decker T, Hume D.A., Dalpke A.H., Sweet M.J. (2007). Differential effects of CpG DNA on IFN-beta induction and STAT1 activation in murine macrophages versus dendritic cells: alternatively activated STAT1 negatively regulates TLR signaling in macrophages. J. Immunol. 179:3495-3503
• Rae, F., Woods, K., Sasmono, T., Campanale, N., Taylor, D., Ovchinnikov, D., Grimmond, S.M., Hume, D.A., Ricardo, S., Little, M.H. (2007). Characterisation and trophic functions of murine embryonic macrophages based upon the use of a CSF-1R-EGFP transgene reporter. Devel. Biol. 308:232-246
• Ripoll, V.M., Ravasi, T., Irvine, K.M., Sweet, M.J., Hume, D.A. (2007) Gpnmb is induced in macrophages by IFN-gamma and lipopolysaccharide and acts as a feedback regulator of proinflammatory processes. J.Immunol. 178:6557-6666
• Forwood, J.K., Thakur, A.S., Guncar, G., Marfori, M., Mouradov, D., Meng, W., Robinson, J., Kellie, S., Martin, J.L., Hume, D.A., Huber, T., Kobe, B. (2007) Structural and functional basis for recruitment of tandem hotdog domains in acyl-coA thioesterase 7. Proc. Nat. Acad. Sci. (USA). 104:10382-10387
• McMorran, B.J., Ouvry Patat, S.A., Carlin, J.B., Grimwood, K., Jones, A., Armstrong, D.S., Galati, J.C., Cooper, P.J., Byrnes, C.A., Francis, P.W., Robertson, C.F., Hume, D.A., Borchers, C.H., Wainwright, C.E., Wainwright, B.J. (2007) Proteomic profiling reveals novel markers of the exaggerated pulmonary inflammatory response in paediatric cystic fibrosis bronchoalveolar lavage fluid. Clin. Chem. 53:1782-1791
• Schroder, K., Lichtinger, M., Irvine, K.M., Brion, K., Trieu, A., Ross, I.L., Ravasi, T., Stacey, K.J., Rehli, M., Hume, D.A. & Sweet, M.J. (2007). Pu.1 and ICSBP control constitutive and IFN-gamma-regulated tlr9 gene expression in mouse macrophages. J. Leukocyte Biol. 81:1577-1590
• Hinshelwood, R.A., Huschtscha, L.I., Melki, J., Stirzaker, C., Abdipranoto, A., Vissel, B., Ravasi, T., Wells, C.A., Hume, D.A., Reddel, R.R. & Clark, S.J. (2007). Concordant epigenetic silencing of TGFb signalling pathway genes occurs early in breast carcinogenesis. Cancer Res. 67:11517-11527
2008
• Ovchinnikov, D.A., van Zuylen, W., de Bats, C.E., Alexander, K.A., Kellie, S., Hume, D.A. (2008) Expression of gal4-dependent transgenes in cells of the mononuclear phagocyte system labeled with enhancer cyan fluorescent protein using csf1r-gal4VP16/UAS-ECFP double-transgenic mice. J.Leukocyte Biol. 83:430-433
• Hadler, K.S., Huber, T., Cassady, A.I., Weber, J.E., Robinson, J., Burrows, A., Kelly, G., Guddat, L.W., Hume, D.A., Schenk, G. & Flanagan, J.U. (2008). Identification of a non-purple tartrate-resistant acid phosphatase; An evolutionary link to Ser/Thr protein phosphatases. BMC Research Notes 1, 78
• Burke, B., Ahmad, R., Staples, K.J., Snowdon, R., Kadioglu, A., Frankenberger, M., Hume, D.A., Ziegler-Heitbrock. (2008) Increased TNF expression in CD43(++) murine blood monocytes. Immunol. Letts. 118:142-147
• Hume, D.A., Sasmono, T., Himes, S.R., Sharma, S.M., Bronisz, A., Constantin, M., Ostrowski, M.C. & Ross, I.L. (2008) The Ewing sarcoma protein (EWS) binds directly to proximal promoter elements of the macrophage-specific promoter of the CSF-1 receptor (c-fms) gene. J.Immunol. 180:6733-6742
• King, G.J., Jones, A., Kobe, B., Huber, T. Mouradov, D., Hume, D.A. & Ross, I.L. (2008). Identification of disulfide-containmg chemical cross links in proteins using MALDI-TOF/TOF-mass spectrometry. Anal. Chem. 80:5036-5043
• Faulkner, G.J., Forrest, A.R.R., Chalk, A.M., Schroder, K., Hayashizaki, H., Carninci, P., Hume, D.A., Grimmond, S.M. (2008) A rescue strategy for multimapping short sequence tags refines surveys of transcriptional activity by CAGE. Genomics. 91:281-88
• Maeda, N., Nishiyori, H., Nakamura, M., Kawazu, C., Murata, M., Sano, H., Hayashida, K., Fukuda, S., Tagami, M., Hasegawa, A., Murakami, K., Schroder, K., Irvine, K., Hume, D.A., Hayashizaki, Y., Carninci, P., Suzuki, H. (2008) Development of a DNA barcode tagging method for monitoring dynamic changes in gene expression using ultra high throughput sequencer. Biotechniques. 45:95-97
• Lattin, J.E., Schroder, K., Su, A.I., Walker, J.R., Zhang, J., Wiltshire, T., Saijo, K., Glass, C.K., Hume, D.A., Kellie, S. & Sweet, M.J. (2008) Expression analysis of G protein-coupled receptors in mouse macrophages. Immunome Research 4:5
• Ripoll, V.M., Meadows, N.A., Raggatt, L-J., Chang, M.K., Pettit, A.R., Cassady, A.I. & Hume, D.A. (2008) Microphthalmia transcription factor regulates the expression of the novel osteoclast factor GPNMB. Gene 413:32-41
• Pettit, A.R., Hume, D.A., Raggatt, L.J. (2008) Structural and cellular differences between metaphyseal and diaphyseal periosteum in different-aged rats. Bone 42:825-826
• Chang, M.K., Raggatt, Alexander, K.A., Kulibawa, J.S., Fazzalari, N.L., Schroder, K., Maylin, E.R., Ripoll, V.M., Hume, D.A., Pettit, A.R. (2008) Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo. J. Immunol. 181:1232-1244
• Lang, P., van Harmelen, V., Ryden, M., Kaaman, M., Parini, P., Carneheim, C., Cassady, A.I., Hume, D.A., Andersson, G. & Arner, P. (2008) Monomeric Tartrate Resistant Acid Phosphatase induces Insulin Sensitive Obesity. PLoS ONE 3:e1713
• Wells, C.A., Salvage-Jones, J.A., Li, X., Hitchens, K., Butcher, S., Murray, R.Z., Beckhouse, A.G., Lo, Y-S-L, Alonso, S.M., Cobbold, C., Schroder, K., Ma, B., Orr, S., Stewart, L., Lebus, D., Sobieszczuk, P., Hume, D.A., Stow, J.L., Blanchard, H. & Ashman, R.B. (2008) The macrophage inducible c-type lectin, Mincle, is an essential component of the innate immune response to Candida albicans. J.Immunol. 180:7404-7413
• Cowieson, N.P., King, G., Cookson, D., Ross, I., Huber, T., Hume, D.A., Kobe, B., Martin, J.L. (2008) Cortactin adopts a globular conformation and bundles actin into sheets. J.Biol. Chem. 283:16187-16193
2009
• Goh, F., Irvine, K.M., Lovelace, E., Donnelly, S., Jones, M.K., Brion, K., Hume, D.A., Kotze, A.C., Dalton, J.P., Ingham, A. & Sweet, M.J. (2009) Selective induction of the Notch Ligand Jagged-1 in macrophages by soluble egg antigen from Schistosoma mansoni involves ERK signaling. Immmunology. 127:326-337
• Irvine, J.M., Andrews, M.R., Fernandez-Rojo, M.A., Schroder, K., M., Burns, C.J., Su, S., Wilks, A.F., Parton, R.G., Hume, D.A., Sweet, M.J. (2009) Colony-stimulating factor-1 delivers a pro-atherogenic signal to human macrophages. J. Leukocyte Biol. 85:278-288
• Auffray, C., Fogg, D.K., Narni-Mancinelliu, E., Senechal, B., Touillet, C., Saederup, N., Leemput, J., Bigot, K., Campisi, L., Abitbol, M., Molina, T., Charo, I., Hume, D.A., Cumano, A., Lauvauj, G., Geissmann, F. (2009) CX3CR1+, CD115+CD135+ common macrophage/DC precursor (MDP) and the role of CX3CR1 in their response to inflammation. J.Exp.Med. 206:595-606
• Taft, R.J., Glaszov, E.A., Cloonan, N., Simons, Ca., Stephen, S., Faulkner, G., Lassmann, T., Forrest, A.R.R., Grimmond, S., Schroder, K., Irvine, K., Hume, D.A., Suzuki, H., Orlando, V., Carninci, P., Arakawa, T., Nakamura, M., Kubosaki, A., Hayashida, K., Kawazu, C., Murata, M., Nishiyori, H., Kawai, J., Daub, C.O., Hayashizaki, Y., Mattick, J.S. (2009) Tiny RNAs are associated with transcription start sites in animals. Nature Genetics 41:572-578
• Suzuki, H. et al. (FANTOM Consortium and RIKEN Genome Exploration Group) Hume, D.A. named as Senior Author in the Consortium. (2009). The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nature Genetics 41:553-562
• Faulkner, G.J., et al. (2009) (FANTOM Consortium and RIKEN Genome Exploration Group; Hume, D.A. named as last and Senior Author in the Consortium). The regulated retrotransposon transcriptome of mammalian cells. Nature Genetics. 41:563-571
• Roberts, T.L., Idris, A., Dunn, J.A., Kelly, G.M., Burnton, C.M., Hodgson, S., Hardy, L.L., Garceau, V., Sweet, M.J., Ross, I.L., Hume, D.A. & Stacey, K.J. (2009) HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science. 323:1057-1060. (Editor’s Choice Editorial)
• Severin, J, Waterhouse, A.M., Kawaji, H., Lassmann, T., van Nimwegen, E., Balwierz, P.J., de Hoon, M.J.L., Hume, D.A., Carninci, P., Hayashizaki, Y., Suzuki, H., Daub, C.O. & Forrest, A.R.R. (2009) FANTOM4 EdgeExpressDB: an integrated database of genes, microRNAs, their promoters, expression dynamics and regulatory interactions. Genome Biology 10:R39
• Forrest, A.R.R., Kanamori-Katayama, M., Tomaru, Y., Lassmann, T., Ninomiya, N., Takahashi, Y., Kaiho, A., de Hoon, M.J.L., Kubosaki, A., Kaiho, A., Suzuki, M., Yasuda, J., Kawai, J., Hayashizaki, Y., Hume, D.A., Suzuki, H. (2009) Induction of microRNAs mir-155, mir-222, Mir-424 and mir-503 promotes monocytic differentiation through combinatorial regulation. Leukemia Epub Dec 3
• Kawaji, H., Severin, J., Lizio, M., Waterhouse, A., Katayama, S., Irvine, K.M., Hume, D.A., Forrest, A.R.R., Suzuki, H., Carninci, P., Hayashizaki, Y. & Daub, C.O. (2009) The FANTOM Web Resource: From Mammalian Transcriptional Landscape to its Dynamic Regulation. Genome Biology 10:R40
• Trieu, A., Bokil, N./, Dunn, J.A., Roberts, T.L., Xu, D., Liew, F.Y., Hume, D.A., Stacey, K.J. & Sweet, M.J. (2009) TLR9-independent effects of inhibitory oligonucleotides on macrophage responses to S.typhimurium. Immunol. Cell Biol. 87:218-225
• Dave, R.K., Hume, D.A., Elsegood, C., Kellie, S. (2009) CD148/DEP-1 association with areas of cytoskeletal organization in macrophages. Exp. Cell. Res. 315:1734-1744.
• Weber, J.E., Oakley, A.J., Christ, A.N., Hall, R., Clark, A., Hayes, J., Hume, D.A, Board, P.G, Smythe, M.L, Flanagan, J.U (2009) Identification and characterization of new inhibitors for the human hematopoietic prostaglandin D2 synthase. Eur.J.Med.Chem. In press. Epub Oct23
• Lattin, J.E., Greenwood, K.P., Daley, N.L., Kelly, G., Zidar, D.A., Clark, R.J., Thomas, W.G., Kellie, S., Craik, D.J., Hume, D.A. & Sweet, M.J. (2009) Beta-arrestin 2 is required for complement C1Q expression in macrophages and constrains factor-independent survival. Molecular Immunol. 47:340-347
• Ebert, S., Weigelt, K., Walczak, Y., Drobnik, W., Mauerer, R., Hume, D.A., Weber, B.H.F. & Langmann, T. (2009) Docosahexaenoic acid attenuates microglial activation during retinal degeneration. J. Neurochem 110:1863-1875
• Mar, J.C., Kimura, Y., Schroder, K., Irvine, K.M., Hayashizaki, Y., Suzuki, H., Hume, D.A. & Quackenbush, J. (2009). Data-driven normalisation strategies for high-throughput quantitative RT-PCR. BMC Bioinformatics. 10:110
• Summers, K.M., Bokil, N.J., Baisden, J.M., West, M.J., Sweet, M.J., Raggatt, L-J., Hume, D.A. (2009) Experimental and bioinformatic characterisation of the promoter region of the Marfan syndrome gene, FBN1. Genomics. 94:233-240
2010
• Forrest, A.R.R., Kanamori-Katayama, M., Tomaru, Y., Lassmann, T., Ninomiya, N., Takahashi, Y., Kaiho, A., de Hoon, M.J.L., Kubosaki, A., Kaiho, A., Suzuki, M., Yasuda, J., Kawai, J., Hayashizaki, Y., Hume, D.A., Suzuki, H. (2010) Induction of microRNAs mir-155, mir-222, Mir-424 and mir-503 promotes monocytic differentiation through combinatorial regulation. Leukemia 24:460-466
• Weber, J.E., Oakley, A.J., Christ, A.N., Hall, R., Clark, A., Hayes, J., Hume, D.A, Board, P.G, Smythe, M.L, Flanagan, J.U (2010) Identification and characterization of new inhibitors for the human hematopoietic prostaglandin D2 synthase. Eur.J.Med.Chem. 45:447-454
• Mooney, J., Rolfe, B., Osborne, G., Sester, D.P., van Rooijen, N., Campbell, G., Hume, D.A. & Campbell, J. (2010) Cellular plasticity of inflammatory myeloid cells in the peritoneal foreign body response. Am. J. Pathol. 176:369-380
• Deng, L., Zhou, J-F., Sellers, R.S., Li, J-F., Nguyen, A.V., Wang, Y., Orlofsky, A., Liu, Q., Hume, D.A., Pollard, J.W., Augenlicht, L. & Lin, E.Y. (2010) A novel mouse model of inflammatory bowel disease links mTOR-dependent hyperproliferation of colonic epithelium to inflammation-associated tumorigenesis. Am. J. Pathology 176:952-967
• Ripoll, V., Kadioglu, A., Hume, D.A., Cox, R., Denny, P. (2010) Macrophages from BALB/c and CBA/Ca mice differ in their cellular responses to Streptococcus pneumoniae. J.Leukocyte Biol. 87:735-741
• Garceau, V., Jacqueline, J., Paton, I.R., Davey, M., Fares, M.A., Sester, D.P., Burt, D.W. & Hume, D.A. (2010) Pivotal Advance: Avian colony-stimulating factor 1 (CSF-1), interleukin 34 (IL34) and CSF-1 receptor genes and gene products. J.Leukocyte Biology. 87:753-764
• Halili, M.A., Andrews, M.R., Labzin, L.I., Schroder, K., Matthias, G., Cao, C. Lovelace, E., Reid, R., Le, G.T., Hume, D.A., Irvine, K.M., Matthias, P., Fairlie, D.P. & Sweet, M.J. (2010). The differential effects of HDAC inhibitors on macrophage inflammatory responses to Toll-like receptor agonist LPS are separable: Implications for targeting inflammatory disease J.Leukocyte Biol. 87:1103-1114
• Ravasi, T. et al. (2010) The FANTOM Consortium and RIKEN Omics Science Center (Hume, D.A. named as senior author in the consortium and joint last author). An atlas of combinatorial transcriptional regulation in mouse and man. Cell. 140:744-752
• Ovchinnikov, D.A., deBats, C.E.E., Sester, D.P., Sweet, M.J., Hume, D.A. (2010). A conserved distal segment of the mouse CSF-1 receptor promoter is required for maximal expression of a reporter gene in macrophages and osteoclasts of transgenic mice. J.Leukocyte Biol. 87:815-822
• Hume, D.A., Summers, K.M., Raza, S. & Freeman, T.C. (2010). Functional clustering and lineage markers: Insights into cellular differentiation and gene function from large scale microarray studies of purified primary cell populations. Genomics. 95:328-338
• Summers, K.M., Raza, S., van Nimwegen, E., Freeman, T.C. & Hume, D.A. (2010) Co-expression of FBN1 with mesenchyme-specific genes in mouse cell lines: implications for phenotypic variability in Marfan syndrome. Eur. J. Clin. Genetics. 18: 1209-1215
• Kubosaki, A., Lindgren, G., Tagami, M., Simon, C., Tomaru, Y., Miura, H., Suzuki, T., Arner, E., Forrest, A.R.R., Irvine, K.M., Schroder, K., Hasegawa, Y., Kanamori-Katayama, M., Rehli, M., Hume, D.A., Kawai, J., Suzuki, M., Suzuki, H., Hayashizaki, Y. (2010) The combination of gene perturbation assay and ChIP-chip reveals functional direct target genes for IRF8 in THP-1 cells. Mol. Immunol. 47:2295-2302
• Macdonald, K.P.A., Palmer, J.S., Cronau, S., Seppanen, E., Olver, S., Raffelt, N.C., Kuns, R., Pettit, A.R., Clouston, A., Wainwright, B., Branstetter, D., Smith, J., Paxton, R.J., Cerretti, D.P., Bonham, L., Hill, G.R. & Hume, D.A. (2010) An antibody against the colony-stimulating factor receptor (CSF1R) depletes the resident subset of monocytes and tissue and tumour-associated macrophages but does not inhibit inflammation. Blood 116:3955-3963
• Mabbot, N, Baillie, J.K., Hume, D.A. (joint last author), Freeman, T.C. (2010). Meta-analysis of lineage-specific gene expression signatures in mouse leukocyte populations. Immunobiology 215:724-736
2011
• Van Zuylen, W.J., Garceau, V., Idris, A., Schroder, K. Schroder, K.M., Lattin, J.E., Ovchinnikov, D.A., Perkins, A.C., Cook, A.D., Hamilton, J.A., Hzterzog, P.A., Stacey, K.J., Kellie, S., Hume, D.A*., Sweet, M.J. (2011) Macrophage activation and differentiation signals regulate schlafen-4 gene expression: Evidence for schlafen-4 as a modulator of myelopoiesis. PLOS One 6:e15723
• Roberts, T.L., Dunn, J.A., Sweet, M.J., Hume, D.A., Stacey, K.J. (2011) The immunostimulatory activity of phosphorothioate oligonucleotides is affected by distal sequence changes. Mol. Immunol. 48: 1027-1034
• Alikhan, M.A., Jones, C.V., Fletcher, A.L., Williams, T.M., Sakkal, S., Campanale, N.V., Kett, M.M., Samuel, C.S., Deane, J.A., Bertram, J.F., Little, M.H., Hume, D.A. (joint last author), Ricardo, S.D. (2011) CSF-1 promotes kidney developmental and postnatal repair via alteration of a macrophage response. Am. J. Pathol. 179: 1243-1256
• Schroder, K., Irvine, K.M., Taylor, M.S., Semple, C.A., Akalin, A., Cao, K-A, L. Labzin, L., Bokil, N., Faulkner, G.J., Baillie, J.K., Gongora, M., Daub, C.O., McLachlan, G., Grimmond, S.M., Carninci, P., Suzuki, H., Hayashizaki, Y., Lenhard, B., Hume, D.A. (joint last author) & Sweet, M.J. (2011). The evolution of gene regulation in innate immunity between mouse and human reveals multiple paths to divergence. Genome Biology Revision submitted.
• Alexander, K.A., Chang, M.K., Maylin, E.R., Kohler, T., Wu, A.C., van Rooijen, N., Sweet, M.J., Hume, D.A., Raggatt, L., Pettit, A.R. (2011) Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model. J.Bone Mineral. Res. 26: 1517-1532
• Thomas, J.A., Pope, C., Wojtacha, D., Gordon-Walker, T., Robson, A., Hartland, S., Ramachandran, P., Hume, D.A., Iredale, J.P., Forbes, S.J. (2011) Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration and function. Hepatology. 53: 2003-2015
• Doig, T.N., Goodlad, J.R., Gregory, C.D., Hume, D.A., Freeman, T.C. (2011) Network analysis of the cancer transcriptome. PNAS Submitted.
• Fairbairn, L., Kapetanovic, R., Sester, D.P. & Hume, D.A. (2011) The mononuclear phagocyte system of the pig as a model for understanding human innate immunity and disease. J.Leukocyte Biol. 89: 855-871
• Bradford, B. M., Sester, D. P., Hume, D. A., Mabbott, N. A. (2011). Defining the anatomical localisation of subsets of the murine mononuclear phagocyte system using integrin alpha X (Itgax, CD11c) and colony stimulating factor 1 receptor (Csf1r, CD115) expression fails to discriminate dendritic cells from macrophages. Immunobiology 216: 1228-1237.
• Baillie, J. K., Barnett, M. W., Upton, K. R., Gerhardt, D. J., Richmond, T. A., De Sapio, F., Brennan, P., Rizzu, P., Smith, S., Fell, M., Talbot, R. T., Gustincich, S., Freeman, T. C., Mattick, J. S., Hume, D. A., Heutink, P., Carninci, P., Jeddeloh, J. A., Faulkner, G. J. (2011). Somatic retrotransposition alters the genetic landscape of the human brain. Nature 479: 534-537.
• Robert, C., Lu, X., Law, A., Freeman, T. C., Hume, D. A. (2011). Macrophages.com: An on-line community resource for innate immunity research. Immunobiology 216: 1203-1211.
• Hume, D. A. (2011). Applications of myeloid-specific promoters in transgenic mice support in vivo imaging and functional genomics but do not support the concept of distinct macrophage and dendritic cell lineages or roles in immunity. Journal of Leukocyte Biology 89: 525-538.
• Hume, D. A., Whitelaw, C. B. A., Archibald, A. L. (2011). The future of animal production: improving productivity and sustainability. Journal of Agricultural Science 149: 9-16.
2012
• Hume, D.A. & Macdonald, K.P. (2012). Therapeutic applications of macrophage colony-stimulating factor (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling. Blood 119: 1810-1820.
• Kapetanovic, R., Fairbairn, L., Beraldi, D., Sester, D.P., Archibald, A.L., Tuggle, C.K. & Hume, D.A. (2012). Pig Bone Marrow-Derived Macrophages Resemble Human Macrophages in Their Response to Bacterial Lipopolysaccharide. Journal of Immunology, 188: 3382-3394.
• Everitt, A.R., Clare, S., Pertel, T., John, S.P., Wash, R.S., Smith, S.E., Chin, C.R., Feeley, E.M., Sims, J.S., Adams, D.J., Wise, H.M., Kane, L., Goulding, D., Digard, P., Anttila, V., Baillie, J.K., Walsh, T.S., Hume, D.A., Palotie, A., Xue, Y., Colonna, V., Tyler-Smith, C., Dunning, J., Gordon, S.B., The GenISIS Investigators, The MOSAIC Investigators, Smyth, R.L., Openshaw, P.J., Dougan, G., Brass, A.L. & Kellam, P. (2012). IFITM3 restricts the morbidity and mortality associated with influenza. Nature, E-pub 27 March.
• Schroder, K., Irvine, K.M., Taylor, M.S., Bokil, N.J., Le Cao, K.A., Masterman, K.A., Labzin, L.I., Semple, C.A., Kapetanovic, R., Fairbairn, L., Akalin, A., Faulkner, G.J., Baillie, J.K., Gongora, M., Daub, C.O., Kawaji, H., McLachlan, G.J., Goldman, N., Grimmond, S.M., Carninci, P., Suzuki, H., Hayashizaki, Y., Lenhard, B., Hume, D.A. & Sweet, M.J. (2012). Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages. Proceedings of the National Academy of Sciences of the United States of America, E-pub 28 March.
PATENTS
• Hume, D.A. & Sweet, M.J. (1995) Bioassay (A cell line based assay for the detection of endotoxin and compounds with endotoxin-like activities). Australian Provisional Patent #PN4356. Filed 24 July, 1995.
• Hamilton, S.E., de Jersey, J., Cassady, A.I. & Hume, D.A. (1998) Inhibitors of purple acid phosphatases (PAP). Australian Provisional Patent Filed December, 1998. Refiled in expanded form, December 2000. PCT Filed June, 2001.
• Hume, D.A., Sweet, M.J., Sester, D.P., Stacey, K.J. (1998). Immunostimulatory nucleic acids. Australian Provisional Patent filed 26th November, 1998. PCT Filed 26th November, 1999. National Phase, June 2001.
• Hume, D.A., Stacey, K.J., Sester, D.P., Sweet, M.J., CSF-1 Immunomodulation. Provisional Patent PR8071 filed October 3, 2001. PCT Filed October 3rd, 2002.
• M.H.Little, K.Woods, D.A. Hume Renal repair and regeneration. Provisional Patent 2002901346. Filed 18/3/2005. PCT Filed 17th March, 2006.
• Stacey, K.J., Roberts, T., Hume, D.A. DNA-binding protein, nucleoprotein complex and method of use. Provisional Patent #2006904919, Filed September 7, 2006.
• Ricardo, S., Little, M.H., Hume, D.A. Therapy for low birth weight or prematurity. Provisional patent filed October 3rd, 2006. PCT Filed September 17th, 2007; National Phase March 2009
• Hume, D.A., Garceau, V., Burt, D., Smith, J. Sester, D.P. Avian CSF-1 and IL34 and uses thereof. UK provisional. 16 June
BOOKS, REVIEWS AND PUBLISHED CONFERENCE PROCEEDINGS
• Hume, D.A. & Weidemann, M.J. (1979) Role and regulation of glucose metabolism is proliferating cells. J. Natl. Cancer Inst. 62: 1-9
• Hume, D.A. & Weidemann, M.J. (1980) Mitogenic Lymphocyte Transformation: A General Model for the Control of Mammalian Cell Proliferation. Research Monographs in Immunology. Elsevier North-Holland Biomedical Press, Amsterdam. 251pages
• Hume, D.A. & Gordon, S. (1982) Macrophage Biochemistry. Life Chemistry Reports 1:1-49
• Hume, D.A. & Gordon, S. (1985) The mononuclear phagocyte system of the mouse defined by immunohistochemical localisation of antigen F4/80. In. Mononuclear Phagocytes: Characteristics, Physiology and Function. van Furth, R. Ed. Martinus Nijhoff, Amsterdam pp9-16
• Gordon, S., Starkey, P., Hume, D.A., Ezekowitz, R.A.B., Hirsch, S. & Austyn, J. (1985) Plasma membrane markers to study differentiation, activation and localisation of murine macrophages. Ag F4/80 and the mannosyl-fucosyl receptor. Handbook of Experimental Immunology. Weir, D.M., Herzenberg, L.A., Blackwell, C. & Herzenberg, L.A. Eds. Blackwell Scientific Publications, Oxford, UK. Vol 2, Chapter 43
• Hapel, A.J., Hume, D.A., Allan, W., Osborne, J.M. & Warren, H.S. (1985) Assays for interleukin 3 are not specific. In. Cellular and Molecular Biology of Lymphokines. Sorg, C., Schimpl, A. & Landy, M. Eds. Academic Press, New York. pp443-448
• Hume, D.A. (1985) The Biology of Macrophages. Science Progress 69: 485-498
• Gordon, S., Crocker, P., Morris, L., Lee, S.H., Perry, V.H. & Hume, D.A. (1986) Localisation and function of tissue macrophages. In "Biochemistry of Macrophages"CIBA Foundation Symposium 118: 54-67
• Hume, D.A. & Doe, W.F. (1988) Role of macrophages in cellular defence. In Immunology of the Gastrointestinal Tract and Liver. Heyworth, M.F. & Jones, A.L. Eds. Raven Press, New York. pp23-46
• Hume, D.A. (1990) Macrophage colony-stimulating factor. Today's Life Sciences 2: 20-28
• Pavli, P., van der Pol, E., Hume, D.A. & Doe, W.F. (1990) Mucosal macrophages and dendritic cells. In Mucosal Immunology. Cripps, A.W. (Ed) Newcastle, Newey & Beath p46-51
• Le. F., Wilce, P.A., Cassady, I, Hume, D.A. & Shanley, B.C. (1991). Acute administration of ethanol suppresses pentylenetetrazole-induced c-fos expression in rat brain. In: Advances in Biomedical Alcohol Research. Ed. Kalant, H., Khanna, J.M. & Israel, Y. Pergamon Press. 211-214.
• Stacey, K.J., Cassady, A.I., Nimmo, K., Murphy, K.M., von der Ahe, D., Pearson, D., Botteri, F.M., Nagamine Y. & Hume , D.A. (1992) Regulation of urokinase plasminogen activator gene expression in macrophages In Mononuclear Phagocytes: Biology of monocytes and macrophages. van Furth, R.(Ed). Kluwer Academic Publishers. p233-243.
• Le F., Wilce, P., Hume, D.A., Shanley, B. (1993) Effect of acute and chronic administration of ethanol on c-fos expression in brain. In: Alcohol, cell membranes and signal transduction in brain. Ed. C. Alling. Plenum Publishing, New York.
• Hume, D.A. (1994) Research Funding in Australia. Plugging the Brain Drain (A transcript of a submission to the Senate Standing Committee on Employment, Education and Training's Inquiry into the Organisation and Funding of Research in Higher Education). Search 25: 27-31
• Hume, D.A., Stacey, K.J., Cassady, A.I., Browne, C.M., Sweet, M.J. Bertoncello, I. (1997) Growth and Differentiation of Murine Macrophages. In: THE HANDBOOK OF EXPERIMENTAL IMMUNOLOGY (5th edition), Volume 4: The Integrated Immune System, Section 26: The Myeloid System, Chapter 160. Blackwell C.A. and Herzenberg L.A. (Eds.) Blackwell Science, Boston. pp. 160.1-160.10.
• Sweet, M.J. & Hume, D.A. (1996) Endotoxin signal transduction in macrophages. J. Leukocyte Biology. 60: 8-26 (Received Dolph Adams Award for most cited review in the journal for the 5 years to 2000).
• Hume, D.A., Yue, X., Ross, I.L., Favot, P., Lichanska, A., Ostrowski, M.C. (1997) Regulation of CSF-1 receptor expression. Molecular Reproduction and Development. 46:46-52
• Sester, D.P., Stacey, K.J., Sweet, M.J., Beasley, S., Cronau, S. Hume, D.A. (1999). The effects of CpG DNA on macrophages. Journal of Leukocyte Biology. 66:542-548
• Passey, R.J., Xu, K., Hume, D.A. & Geczy, C.L. (1999). S100A8: Emerging functions and regulation. Journal of Leukocyte Biology. 66:549-556
• Hume, D.A. (1999) Young scientists in biomedical research. Science 284:49 (Correspondence).
• X. Yue, C. Chen & Hume, D.A. (2001) Transcriptional regulation of c-fms gene expression. Cell Biochemistry and Biophysics. 34:1-16.
• Oddie, G.W., Schenk, G., Angel, N.Z., Walsh, N., Guddat, L., de Jersey, J., Cassady, A.I., Hamilton, S.E., Hume, D.A. (2000) Structure, function and regulation of mammalian tartrate-resistant acid phosphatases. Bone 27:575-584
• Stacey, K.J., Sester, D.P., Sweet, M.J. & Hume, D.A. (2000) Macrophage activation by immunostimulatory DNA. Current Topics in Microbiology and Immunology. 247:41-58
• Lichanska, A. & Hume, D.A. (2000) Origins and functions of phagocytes in the embryo. Exp. Hematol. Review. 28:601-611
• Aderem, A. & Hume, D.A. (2000) How do you see CG? Cell 103:993-996 .
• Stacey, K.J., Sester, D.P., Naik, S., Roberts, T., Sweet, M.J. & Hume, D.A. (2002). Phosphorothioate backbone modification changes the pattern of responses to CpG motifs in oligonucleotides. In “Microbial DNA and Immune Modulation” Ed. E. Raz. Humana Press. Totawa, NJ. Pp63-77
• Hume, D.A., Ross, I.L., Himes, S.R., Sasmono, T., Wells, C.A., Ravasi, T. 2002. The mononuclear phagocyte system revisited. J. Leukocyte Biology. 72:621-627
• Hume, D.A. 2002. Towards a systems biology view of macrophage and osteoclast function. Australian Biochemist. 33:10-12.
• Himes, S.R. & Hume, D.A. (2003). Transcription factors that regulate macrophage development and function. In. “The macrophage as therapeutic target.” Handbook of Experimental Pharmacology. 158: 11-40 Springer-Verlag.
• R.T.Sasmono & D.A. Hume (2004) The biology of macrophages. In “The Innate Immune response to Infection”. S.Kaufmann, S.Gordon & R.Medzhitov. Eds. Am. Society for Microbiology Press. pp71-94
• Sweet, M.J. & Hume, D.A. (2003) CSF-1 as a regulator of macrophage activation and immune responses. Archivum Immunologiae et Therapiae Experimentalis (AITE) 51:169-177
• Okazaki, Y. & Hume, D.A. (2003) A guide to the mammalian genome. Genome Res. 13:1267-1272
• Schroder, K., Hertzog, P., Ravasi, T., Hume, D.A. (2004) Interferon-gamma. An overview of signals, mechanisms, and functions. J. Leukocyte Biol. 75:163-189
• Irvine, K., Stirling, R., Hume, D.A. & Kennedy, D. (2005). Rasputin, more promiscuous than ever: A review of G3BP. Int. J. Dev. Biol. 48:1065-1077
• Wells, C.A., Ravasi, T., Hume, D.A. (2005) Inflammation suppressor genes-Please turn out all the lights. J. Leukocyte Biol. 78:9-13
• Ravasi, T. & Hume, D.A. (2005) Non-coding RNA in mammals. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. Wiley press. (http://www.wiley.com/legacy/wileychi/ggpb/)
• Tse, B., Hume, D.A., Y-P,P.Chen (2005) Pattern matching motifs In Bioinformatic Technologies. Editor Y.Chen. Springer Berlin. p299-312
• Hume, D.A. & Fairlie, D.P. (2005) Therapeutic targets in inflammatory disease. Current Medicinal Chemistry. 12:2925-2929
• Hume, D.A. Hertzog, P. (2005) Innate Immunity Current Opinion in Immunology. 18:1-4
• Hume, D.A. (2005) The mononuclear phagocyte system. Current Opinion in Immunology. 18:49-53
• Henson, P.M. & Hume, D.A. (2006) Apoptotic cell removal in development and tissue homeostasis. Trends in Immunology. 27:244-250.
• Hume, D.A., Wells, C.A. & Ravasi, T. (2006) Transcriptional regulatory networks in macrophages. Novartis Foundation Symp. 281. Decoding the Genomic Control of Immune Reactions. pp2-18
• Sharma, S.M., Hu., R., Broniksz, A., Meadows, N., Lusby, P., Fletcher, B., Hume, D.A., Cassady, A.I. & Ostrowski, M.C. (2006) Genetics and genomics of osteoclast differentiation: Integrating cell signalling pathways and gene networks. Critical reviews in Eukaryotic Gene Expression. 16:253-277.
• Puri, M., Robin, G., Cowieson, N., Listwan, P., Hu, S-H., Guncar, G., Huber, T., Kellie, S., Hume, D.A., Kobe, B., Martin, J.L. (2006) Focussing in on structural genomics: the University of Queensland structural biology pipeline. Biomolecular Engineering. 23:281-289
• Sandelin, A., Carninci, P., Ponjavic, J., Lenhard, B., Hayashizaki, Y. & Hume, D.A. (2007) Promoting mammalian transcription: Insights into RNA polymerase II core promoter architecture and function from genome-wide promoter identification. Nature Reviews Genetics. 8:424-436
• Lattin, J., Zidar, D.A., Kellie, S., Hume, D.A. & Sweet, M.J. (2007) G-protein coupled receptor expression, function and signalling in macrophages. J.Leukocyte Biol. 82:16-32
• Ravasi, T., Wells, C.A. & Hume, D.A. (2007) Systems biology of transcription control in macrophages. Bioessays 29:1215-1226
• Ferrante, A., Hii, C. & Hume, D.A (2007) Neutrophilic schizophrenia: breaching the barrier between innate and adaptive immunity. Immunol. Cell Biol. 85:265-266
• Meng, W., Forwood, J.K., Guncar, G., Robin, G., Cowieson, N.P., Listwan, P., Mouradov, D., King, G., Ross, I.L., Robinson, J., Hill, J., Kellie, S., Huber, T., Hume, D.A., Martin, J.L., Kobe, B. (2008). Overview of the pipeline for structural and functional characterization of macrophage proteins at the University of Queensland. In Structural Proteomics: High Throughput Methods. Methods Mol. Biol. 426-577-587
• Mouradov, D., Forwood, J.K., King, G., Ross, I.L., Hume, D.A., Sinz, A., Martin, J.L., Kobe, B., Huber, T. (2008) Protein structure determination using a combination of cross-linking, mass spectrometry and molecular modelling. In Structural Proteomics, High throughput methods. Methods Mol. Biol. 426:459-474
• Cowieson, N.P., Wensley, B., Robin, G., Guncar, G., Forwood, J., Hume, D.A., Kobe, B., Martin, J.L. (2008) A medium or high throughput protein refolding assay. . In Structural Proteomics, High throughput methods. Methods Mol. Biol. 426:269-275
• Robin, G., Cowieson, N.P., Guncar, G., Forwood, J., Listwan, P., Hume, D.A., Kobe, B., Martin, J.L., Huber, T. (2008) A general target selection method for crystalographic proteomics. In Structural Proteomics, High throughput methods. Methods Mol. Biol. 426:27-35
• Bonifer, C. & Hume, D.A. (2008) The transcriptional regulation of the colony-stimulating factor 1 recptor (csf1r) gene during haematopoiesis. Front.Biosci. 13:549-560
• Hume, D.A. (2008) Bring out your dead. Nature Immunology (News and Views). 9:12-14
• Hume, D.A. (2008) Macrophages as antigen-presenting cells and the dendritic cell myth. J.Immunol. 181:5829-5835
• Pettit, A.R., Chang, M.K., Hume, D.A., Raggatt, L-J. (2008) Osteal macrophages: a new twist on coupling during bone dynamics. Bone 43:976-982
• Hume, D.A. (2008) Differentiation and heterogeneity in the mononuclear phagocyte system. Mucosal Immunology 1: 432-441
• Hume, D.A. (2008) Our evolving knowledge of the transcriptional landscape. Mammalian Genome. 19:663-666
• Hume, D.A.,Schroder, K., Irvine, K.M. (2009) The impact of CAGE data on understanding macrophage transcriptional biology. In Cap Analysis Gene Expression (CAGE). The Science of Decoding Gene Transcription. Carninci P. Ed. Pan Stanford Publishing.
• Hume, D. (2009), "Macrophages and systems biology", in Gordon, S. (ed.), Innate Immunity: Host recognition and response in health and disease, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://www.hstalks.com/?t=BL0612053-Hume)
• Hume, D.A. (2009), "Macrophages and systems biology", in Gordon, S. (ed.), Innate Immunity: Host recognition and response in health and disease, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://www.hstalks.com/?t=BL0612053-Hume)
• Geissmann, F., Gordon, S., Hume, D.A., Mowatt, A.M., Randolph, G. (2010) (Equal authors) Unravelling mononuclear phagocyte heterogeneity. Nature Rev. Immunol. 10:453-460
• Gow, D.J., Sester, D.P. & Hume, D.A. (2010) CSF-1, IGF-1 and the control of postnatal growth and development. J.Leukocyte Biol. 88:475-481
• Hume, D.A., Whitelaw, C.B.A., Archibald, A.L. (2010) The future of animal production-Improving productivity and sustainability. Foresight Review. J.Agriculture Res 149: 9-16
• Hume, D.A. (2010) Applications of myeloid-specific promoters in transgenic mice support in vivo imaging and functional genomics, but do not support the concept of distinct macrophage and dendritic cell lineages or roles in immunity. J .Leukocyte Biol. 89: 525-538 Selected by Faculty of 1000
• Hume, D. A. (2011). "Editorial." Immunobiology 216(11): 1163.