Key References
Ravasi, T., Wells, C.A. & Hume, D.A. (2007) Systems biology of transcription control in macrophages. Bioessays 29:1215-1226
Bonifer, C. & Hume, D.A. (2008) The transcriptional regulation of the colony-stimulating factor 1 recptor (csf1r) gene during haematopoiesis. Front.Biosci. 13:549-560
Sandelin, A., Carninci, P., Ponjavic, J., Lenhard, B., Hayashizaki, Y. & Hume, D.A. (2007) Promoting mammalian transcription: Insights into RNA polymerase II core promoter architecture and function from genome-wide promoter identification. Nature Reviews Genetics. 8:424-436
Ovchinnikov, D.A., van Zuylen, W., de Bats, C.E., Alexander, K.A., Kellie, S., Hume, D.A. (2007) Expression of gal4-dependent transgenes in cells of the mononuclear phagocyte system labeled with enhancer cyan fluorescent protein using csf1r-gal4VP16/UAS-ECFP double-transgenic mice. J.Leukocyte Biol. 83:430-433
Meadows, N.A., Sharma, S.M., Faulkner, G.J., Ostrowski, M.C., Hume, D.A., Cassady, A.I. (2007). The expression of chloride channel 7 (CLCN7) and OstM1 in osteoclasts is co-regulated by microphthalmia transcription factor. J.Biol. Chem. 282:1891-1904
Ripoll, V.M., Ravasi, T., Irvine, K.M., Sweet, M.J., Hume, D.A. (2007) Gpnmb is induced in macrophages by IFN-gamma and lipopolysaccharide and acts as a feedback regulator of proinflammatory processes. J.Immunol. 178:6557-6666
Sester, D.P., Brion, K., Trieu, A., Goodridge, H.S., Roberts, T.L., Dunn, J., Hume, D.A., Stacey, K.J., Sweet, M.J. (2006) CpG DNA activates survival in murine macrophages through tlr9 and the phosphatidyl inositol 3-kinase-akt pathway. J.Immunol. 177:4473-4480
Aung, H.T., Schroder, K., Himes, S.R., Brion, K., van Zuylen, W., Trieu, A., Suzuki, H., Hayashizaki, Y., Hume, D.A., Sweet, M.J. & Ravasi, T. (2006) LPS regulates pro-inflammatory gene expression in macrophages by altering histone deacetylase expression. FASEB J. 20:1315-27
Hume, D.A., Sasmono, T., Constantin, M., Himes, S.R. & Ross, I.L. (2008) The Ewing sarcoma protein (EWS) binds directly to proximal promoter elements of the macrophage-specific promoter of the CSF-1 receptor (c-fms) gene. J.Immunol. 180:6733-6742
Suzuki, H. et al. (FANTOM Consortium and RIKEN Genome Exploration Group) Hume, D.A. named as Senior Author in the Consortium. (2009). The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nature Genetics 41:553-562
Roberts, T.L., Idris, A., Dunn, J.A., Kelly, G.M., Burnton, C.M., Hodgson, S., Hardy, L.L., Garceau, V., Sweet, M.J., Ross, I.L., Hume, D.A. & Stacey, K.J. (2009) HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science. 323:1057-1060. (Editor’s Choice Editorial)
Macdonald, K.P.A., Palmer, J.S., Cronau, S., Seppanen, E., Olver, S., Raffelt, N.C., Kuns, R., Pettit, A.R., Clouston, A., Wainwright, B., Branstetter, D., Smith, J., Paxton, R.J., Cerretti, D.P., Bonham, L., Hill, G.R. & Hume, D.A. (2010) An antibody against the colony-stimulating factor receptor (CSF1R) depletes the resident subset of monocytes and tissue and tumour-associated macrophages but does not inhibit inflammation. Blood 116:3955-3963