Recent References
Jeffrey M, McGovern G, Chambers EV, King D, González L, Manson JC, Ghetti B, Piccardo P, M Barron R (2012). Mechanism of PrP-amyloid formation in mice without transmissible spongiform encephalopathy. Brain Pathology 22 (1): 58-66
McCulloch L, Brown KL, Bradford B, Hopkins J, Bailey M, Rajewsky K, Manson JC, Mabbott NA. (2011). Follicular dendritic cell-specific prion protein (PRPC) expression alone is sufficient to sustain prion infection in the spleen. PLoS Pathogens 7 (12): e1002402
McCutcheon S, Alejo Blanco AR, Houston EF, de Wolf C, Tan BC, Smith A, Groschup MH, Hunter N, Hornsey VS, Macgregor IR, Prowse CV, Turner M, Manson JC. (2011). All clinically-relevant blood components transmit prion disease following a single blood transfusion: a sheep model of vCJD. PLoS One 6 (8): e23169
Griffiths HH, Whitehouse IJ, Baybutt H, Brown D, Kellett KA, Jackson CD, Turner AJ, Piccardo P, Manson JC, Hooper NM. (2011). Prion protein interacts with bace1 and differentially regulates its activity towards wild type and swedish mutant amyloid precursor protein. Journal of Biological Chemistry 286(38): 33489-33500
Sanchez-Juan P, Bishop MT, Croes EA, Knight RS, Will RG, van Duijn CM and Manson JC (2011) A polymorphism in the regulatory region of PRNP is associated with increased risk of sporadic Creutzfeldt-Jakob disease. BMC Med. Genet. 12(1):73
Krejciova Z, Pells S, Cancellotti E, Freile P, Bishop M, Samuel K, Barclay GR, Ironside JW, Manson JC, Turner ML, De Sousa P.Head MW (2011) Human embryonic stem cells rapidly take up and then clear exogenous human and animal prions in vitro. J. Pathol. 223(5):635-45.
Plinston C, Hart P, Chong A, Hunter N, Foster J, Piccardo P, Manson JC, Barron RM (2011) Increased susceptibility of human-PrP transgenic mice to bovine spongiform encephalopathy infection following passage in sheep. J. Virol 85 (3): 1174-81.
Bishop M, Will R, Manson J (2010) Defining sporadic Creutzfeldt-Jakob disease strains and their transmission properties. PNAS 107 (26):12005-10.
Cancellotti E, Bradford BM, Tuzi NL, Hickey RD, Brown D, Brown KL, Barron RM, Kisielewski D, Piccardo P, Manson JC (2010) Glycosylation of PrPC determines timing of neuroinvasion and targeting in the brain following transmissible spongiform encephalopathies infection by a peripheral route. J. Virol. 84(7): 3464-75.
Bradford BM, Tuzi NL, Feltri ML, McCorquodale C, Cancellotti E, Manson JC. (2009) Dramatic reduction of PrPC level and glycosylation in peripheral nerves following PrP knock-out from Schwann Cells does not prevent transmissible spongiform encephalopathy neuroinvasion. J. Neurosci. 29(49): 15445-54.
Jones M, Wight D, Barron R, Jeffrey M, Manson J, Prowse C, Ironside JW, Head MW. (2009) Molecular model of prion transmission to humans. Emerg. Infect. Dis. 15:2013-6
Jones M, Peden A, Wight C, Prowse C, MacGregor I, Manson J, Turner M, Ironside J, Head M (2008) Effects of Human PrPSc type and PRNP Genotype in an in vitro conversion assay Neuroreport 19(18): 1783-6.
Appleford N E J, Wilson K, Houston F, Bruce L, Morrison A, Bishop M, Chalmers K, Miele G, Massey E, Prowse C, Manson J, Will R, Clinton M, MacGregor, I, Anstee D J (2008). alpha-Hemoglobin stabilizing protein is not a suitable marker for a screening test for variant Creutzfeldt-Jakob disease. Transfusion 48(8): 1616-1626.
Bishop MT, Ritchie DL, Will RG, Ironside JW, Head MW, Thomson V, Bruce M, Manson JC. (2008). No major change in vCJD agent strain after secondary transmission via blood transfusion. PLoS ONE. 3(8):e2878.
Tuzi NL, Cancellotti E, Baybutt H, Blackford L, Bradford B, Plinston C, Coghill A, Hart P, Piccardo P, Barron RM, Manson JC. (2008). Host PrP glycosylation: a major factor determining the outcome of prion infection. PLoS Biol. 6(4):e100.
Barron RM, Campbell SL, King D, Bellon A, Chapman KE, Williamson RA, Manson JC. 2007. High titers of transmissible spongiform encephalopathy infectivity associated with extremely low levels of PrPSc in vivo. J. Biol. Chem. 282(49):35878-86.
Jones M, Peden AH, Prowse CV, Gröner A, Manson JC, Turner ML, Ironside JW, MacGregor IR, Head MW. 2007. In vitro amplification and detection of variant Creutzfeldt-Jakob disease PrPSc. J. Pathol. 213(1):21-6.
Parkin ET, Watt NT, Hussain I, Eckman EA, Eckman CB, Manson JC, Baybutt HN, Turner AJ, Hooper NM. 2007. Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein. PNAS 104(26):11062-7.
Piccardo P, Manson JC, King D, Ghetti B, Barron RM. 2007. Accumulation of prion protein in the brain that is not associated with transmissible disease. PNAS 104(11):4712-7.
Cancellotti E, Barron RM, Bishop MT, Hart P, Wiseman F, Manson JC. 2007. The role of host PrP in Transmissible Spongiform Encephalopathies. Biochim. Biophys Acta. 1772(6):673-80.
Kirby L, Goldmann W, Houston F, Gill AC, Manson JC. 2006. A novel, resistance-linked ovine PrP variant and its equivalent mouse variant modulate the in vitro cell-free conversion of rPrP to PrP(res). J. Gen. Virol. 87(Pt 12):3747-51.
Manson JC, Cancellotti E, Hart P, Bishop MT, Barron RM. 2006. The transmissible spongiform encephalopathies: emerging and declining epidemics. Bioche.m Soc. Trans. 34(Pt 6):1155-8. Review.
Bishop MT, Hart P, Aitchison L, Baybutt HN, Plinston C, Thomson V, Tuzi NL, Head MW, Ironside JW, Will RG, Manson JC. 2006. Predicting susceptibility and incubation time of human-to-human transmission of vCJD. Lancet Neurol. 5(5):393-8.
Cancellotti E, Wiseman F, Tuzi NL, Baybutt H, Monaghan P, Aitchison L, Simpson J, Manson JC. 2005. Altered glycosylated PrP proteins can have different neuronal trafficking in brain but do not acquire scrapie-like properties. J. Biol. Chem. 280(52):42909-18.
Criado JR, Sánchez-Alavez M, Conti B, Giacchino JL, Wills DN, Henriksen SJ, Race R, Manson JC, Chesebro B, Oldstone MB. 2005. Mice devoid of prion protein have cognitive deficits that are rescued by reconstitution of PrP in neurons. Neurobiol. Dis. 19(1-2):255-65.
Barron RM, Baybutt H, Tuzi NL, McCormack J, King D, Moore RC, Melton DW, Manson JC. 2005. Polymorphisms at codons 108 and 189 in murine PrP play distinct roles in the control of scrapie incubation time. J. Gen. Virol. 86(Pt 3):859-68.
Tuzi NL, Clarke AR, Bradford B, Aitchison L, Thomson V, Manson JC. 2004. Cre-loxP mediated control of PrP to study transmissible spongiform encephalopathy diseases. Genesis. 40(1):1-6.
Paisley D, Banks S, Selfridge J, McLennan NF, Ritchie AM, McEwan C, Irvine DS, Saunders PT, Manson JC, Melton DW. 2004. Male infertility and DNA damage in Doppel knockout and prion protein/Doppel double-knockout mice. Am. J. Pathol. 164(6):2279-88.
Barron RM, Thomson V, King D, Shaw J, Melton DW, Manson JC. 2003. Transmission of murine scrapie to P101L transgenic mice. J. Gen. Virol. 84(Pt 11):3165-72.
Barron RM, Manson JC. 2003. A gene-targeted mouse model of P102L Gerstmann-Sträussler-Scheinker syndrome. Clin Lab Med. 23(1):161-73. Review.
McCormack JE, Baybutt HN, Everington D, Will RG, Ironside JW, Manson JC. 2002. PRNP contains both intronic and upstream regulatory regions that may influence susceptibility to Creutzfeldt-Jakob Disease. Gene. 288(1-2):139-46.
Tuzi NL, Gall E, Melton D, Manson JC. 2002. Expression of doppel in the CNS of mice does not modulate transmissible spongiform encephalopathy disease. J. Gen. Virol. 2002 Mar;83(Pt 3):705-11.
Manson JC, Tuzi NL. 2001. Transgenic models of the transmissible spongiform encephalopathies. Expert Rev. Mol. Med. 2001:1-15.